Title:
ナトリウムチャネル遮断薬としてのベンゾアゼピノン
Document Type and Number:
Japanese Patent JP2009543762
Kind Code:
A
Abstract:
Benzazepinone compounds represented by Formula (I), or pharmaceutically acceptable salts thereof. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier. Methods of treating conditions associated with, or caused by, sodium channel activity, including, for example, acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain, epilepsy, irritable bowel syndrome, urinary incontinence, pruritis, itchiness, allergic dermatitis, depression, anxiety, multiple sclerosis, and bipolar disorder, comprise administering an effective amount of the present compounds, either alone, or in combination with one or more other therapeutically active compounds. A method of administering local anesthesia comprises administering an effective amount of a compound of the instant invention, either alone, or in combination with one or more other therapeutically active compounds, and a pharmaceutically acceptable carrier.
Inventors:
Hoyt, Scott Bee
London, Clare
Okay don
Parsons, William H
London, Clare
Okay don
Parsons, William H
Application Number:
JP2009514333A
Publication Date:
December 10, 2009
Filing Date:
June 05, 2007
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D223/16; A61K31/55; A61K45/00; A61P1/04; A61P9/06; A61P13/10; A61P17/00; A61P17/04; A61P23/02; A61P25/00; A61P25/02; A61P25/08; A61P25/18; A61P25/22; A61P25/24; A61P29/00; A61P37/08; A61P43/00; C07D401/12; C07D403/12; C07D409/12; C07D413/12
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura