ベンゾアゼピン誘導体 - Otsuka Pharmaceutical Co., Ltd.

Title:

ベンゾアゼピン誘導体

Document Type and Number:

Japanese Patent JP7055160

Kind Code:

B2

Abstract:

The present invention provides novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V_1a and V₂ antagonisms, for use in the treatment, prevention, and/or diagnosis of a disease selected from the group consisting of Meniere's disease, hypertension, edema, ascites, heart failure, renal dysfunction, renal failure, polycystic kidney disease, syndrome of inappropriate vasopressin secretion, hepatic cirrhosis, hyponatremia, hypokalemia, diabetes, circulation insufficiency, kinesia, water metabolism disorder, and ischemic disorder.In the formula, R¹ is optionally substituted C_1-6 alkyl, etc.; L is -C(=O)-NH-, etc.; Ring A¹ is a hydrocarbon ring, etc.; Ring A² is a hydrocarbon ring, etc.; and each of Rings A¹ and A² may have at least one substituent.

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Inventors:

Keizo Kan
Masanori Taku
Hirotaka Tanaka
Sakae Fujiwara
Hokuto Yamabe
Satoshi Matsuda
Kazuhiro Otatsu
Yasutaka Hanare
Yasuhiro Kojo
Tatsuya Urushijima
Shigekazu Fujita

Application Number:

JP2020067672A

Publication Date:

April 15, 2022

Filing Date:

April 03, 2020

Export Citation:

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Assignee:

Otsuka Pharmaceutical Co., Ltd.

International Classes:

C07D223/16; C07D401/06; C07D401/10; C07D401/12; C07D401/14; C07D403/06

Domestic Patent References:

JP4321669A
JP4154765A
JP6172317A
JP6211800A

Foreign References:

WO2011052519A1
WO1995006035A1

Attorney, Agent or Firm:

Michiko Matsutani
Wu Yingyan

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