Title:
RSV感染の処置または予防用ベンゾジアゼピン
Document Type and Number:
Japanese Patent JP2007529490
Kind Code:
A
Abstract:
Use of a compound which is (a) a benzodiazepine derivative of the formula (I) or an N-oxide thereof or (b) a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing an RSV infection wherein: -R1 represents C1-6 alkyl, aryl or heteroaryl; -R2 represents hydrogen or C1-6 alkyl; each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6alkyl)amino, vitro, cyano, -CO2R', -CONR'R'', -NH-CO-R', -S(O)R', -S(O)2R', -NH-S(O)2R', -S(O)NR'R'' or -S(O)2NR'R'', wherein each R' and R'' is the same or different and represents hydrogen or C1-6 alkyl; n is from O to 3; R4 represents hydrogen or C1-6 alkyl; X represents -CO-, -CO-NR'-, -S(O)- or -S(O)2-, wherein R' is hydrogen or a C1-C6 alkyl group; and R5 represents a heteroaryl or heterocyclyl group which is substituted by a C1C6 hydroxyalkyl group or a -(C1-C4 alkyl)-X1-(C1-C4 alkyl)-X2-(C1-C4 alkyl} group, wherein X1 represents -0-, -S- or -NR'-, wherein R' represents H or a C1-C4 alkyl group and X2 represents -CO-, -SO- or -SO2-, or R5 represents -A1-Y-A2, wherein: -A1 is an aryl, heteroaryl, carbocyclyl or heterocyclyl group; 25 -Y represents a direct bond or a C1-C4 alkylene, -SO2-, -CO-, -0-, -S- or -NR'-moiety, wherein R' is a C1-C6 alkyl group; and -A2 is an aryl, heteroaryl, carbocyclyl or heterocyclyl group.
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Inventors:
Verity dodel
Malcolm Carter
Dagmar Alber
Eliza Henderson
Malcolm Carter
Dagmar Alber
Eliza Henderson
Application Number:
JP2007503411A
Publication Date:
October 25, 2007
Filing Date:
March 18, 2005
Export Citation:
Assignee:
Arrow Therapeutics Limited
International Classes:
C07D243/24; A61K31/5513; A61K31/56; A61K31/58; A61K45/00; A61P11/00; A61P11/06; A61P29/00; A61P31/12; A61P31/16; A61P31/18; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/14; C07D413/12; C07D417/14; C07D471/04
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Mitsutaka Iwasaki
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