BENZOIC ACID AMIDE DERIVATIVE

Japanese Patent JPH01117860

A

NEW MATERIAL:The compound of formula I (R1 is lower alkyl, etc.; R2 is hydroxy, alkoxy, alkenyloxy, etc.; R3 is amino, disubstituted amino, etc.; R4 is halogen, etc., R5 is H or lower alkyl; X is single bond or lower alkylene; Y is single bond, -CH2-, -O-, -S-, etc.; n is 0 or 1; the dotted line is double bond, etc., which may be present when Y is CH2- and n is 0) and its acid addition salt. EXAMPLE:4-Amino-N-[(4-benzyl-1,4-thiomorpholin-2-yl)methyl]-5-chloro-2 -ethoxy benzamide. USE:Antiemetic drug and digestive tract function promoting agent. PREPARATION:The objective compound of formula I can be produced by reacting a compound of formula II or its reactive derivative (e.g., lower alkyl ester) with a compound of formula III in a solvent (e.g., benzene or toluene) or in the absence of solvent.

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KON TATSUYA
KATO SHIROU
MORIE TOSHIYA
KARASAWA TADAHIKO
YOSHIDA NAOYUKI

JP27636987A

May 10, 1989

October 30, 1987

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DAINIPPON PHARMACEUTICAL CO

C07D243/08; A61K31/445; A61K31/495; A61K31/54; A61K31/55; A61K31/554; A61P1/00; A61P1/04; A61P1/14; C07D207/09; C07D211/14; C07D241/02; C07D267/10; C07D279/12; C07D281/06; C07D417/12; (IPC1-7): A61K31/445; A61K31/495; A61K31/54; A61K31/55; C07D207/09; C07D211/14; C07D241/02; C07D243/08; C07D267/10; C07D279/12; C07D281/06; C07D417/12

Kazuaki Kojima

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