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Title:
BENZOTHIAZEPIN COMPOUND
Document Type and Number:
Japanese Patent JPH03264584
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by formula I {R1 and R2 are H or alkyl; R3 is H, alkyl or (substituted) phenylalkyl; R4 and R5 are H, halogen, alkyl, (acyl)amino, OH, nitro, etc.; X is O or NH; R6 is formula II (m is 0 or 1), formula III [R7 is alkyl, (substituted) phenylalkyl, etc.; R8 is H or alkoxy], etc.}.

EXAMPLE: 7-Chloro-5-methyl-N-(3-quinucrydinyl)-2,3,4,5-tetrahydro-1,5 benzothiazepin-9-carboxamide.dihydrochloride.

USE: Motor accelerating agent of stomach, antivomition agent and 5-HT3 receptor blocking agent useful to preventive and treatment for alimentary diseases and treatment for migrim, arrhythmia, anxiety, insanity, dementia, etc.

PREPARATION: A carboxylic acid (reactive derivative) expressed by formula IV is reacted with a compound expressed by the formula R6-XH.


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Inventors:
KAWAKITA TAKESHI
KUROITA TAKANOBU
FUKUDA TAKEMI
IKEZAWA RYUHEI
Application Number:
JP6508590A
Publication Date:
November 25, 1991
Filing Date:
March 14, 1990
Export Citation:
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Assignee:
YOSHITOMI PHARMACEUTICAL
International Classes:
C07D281/10; A61K31/55; A61K31/554; A61P1/04; A61P1/08; A61P1/12; A61P1/14; A61P9/06; A61P25/04; A61P25/06; A61P25/18; A61P25/20; A61P25/28; A61P25/30; C07D417/12; C07D451/12; C07D451/14; C07D453/02; C07D473/00; C07D475/00; (IPC1-7): A61K31/55; C07D281/10; C07D417/12; C07D451/12; C07D451/14; C07D453/02; C07D473/00; C07D475/00
Attorney, Agent or Firm:
Takamiya Castle Masaru



 
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