Title:
BENZOTHIAZEPINE DERIVATIVE
Document Type and Number:
Japanese Patent JPS6351381
Kind Code:
A
Abstract:
Calcium channel blocking activity is exhibited by compounds having the formula or a pharmaceutically accpetable salt thereof, wherein the stereochemistry at the chiral centers in the 3 and 4-positions of the benzothiazepine nucleus is cis, and wherein R1 is alkyl, aryl, arylalkyl, alkenyl or alkynyl; R2 and R5 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen or trifluoromethyl; and R3 and R4 are each independently alkyl or cycloalkyl or R3 and R4 together with the nitrogen atom to which they are attached are pyrrolidinyl, piperidinyl or morpholinyl.
Inventors:
DEBITSUDO MATSUKU FUROIDO
KAANEIRU SHIN ATSUUORU
KAANEIRU SHIN ATSUUORU
Application Number:
JP20734387A
Publication Date:
March 04, 1988
Filing Date:
August 20, 1987
Export Citation:
Assignee:
SQUIBB & SONS INC
International Classes:
A61K31/55; A61K31/554; A61P3/00; A61P3/14; A61P9/00; A61P9/12; C07D281/10; (IPC1-7): A61K31/55; C07D281/10
Attorney, Agent or Firm:
Aoyama Aoi
Previous Patent: Feed water control system
Next Patent: PRODUCTION OF OPTICALLY ACTIVE 2,2-DIMETHYL-4-HALOMETHYL-1,3-DIOXOLANE
Next Patent: PRODUCTION OF OPTICALLY ACTIVE 2,2-DIMETHYL-4-HALOMETHYL-1,3-DIOXOLANE