ＳＴＩＮＧアゴニストとしてのベンゾチオフェン類及び関連する化合物

Japanese Patent JP7326319

B2

Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

WO/2000/000458	SUBSTITUTED PROPIONYL DERIVATIVES AND INTERMEDIATES THEREOF
JP2017511374	Amide compounds, methods of their preparation, and use as agents for the treatment and prevention of diseases and complications caused by RNA and / or DNA-containing viruses.

Altman, michael, dee
Cash, Brandon, Dee
Children, Matthew, Lloyd
Cumming, Jared N
Demong, Duane Yi
Haddle, Andrew Mark
Henderson, Timothy Jay
Jewel, jamie pee
Larsen, Matthew A
Rim, Jong Won
Riu, Min
Otte, Ryan Dee
Trotter, Benjamin Wesley

JP2020553626A

August 15, 2023

April 01, 2019

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Merck Sharp & Dome LLC

C07D277/64; A61K31/381; A61K31/428; A61K31/4365; A61P35/00; A61P37/04; A61P43/00; C07D333/60; C07D417/12; C07D495/04; C07D498/04; C07D519/00

JP2016538344A
JP2016525148A
JP2085281A

Makoto Ono
Kennori Kanayama
Yoshiyuki Tsubokura
Kazuki Shigemori
Kenji Ando
Hidehiko Ichikawa
Yoshie Sakurada
Yosuke Kawasaki
Youichi Iino
Yusuke Ichikawa
Takashi Kawano
Sohei Aya
Takahiro Suzuki
Yoshikazu Iwase
Yasufumi Shiroyama
Takuya Gomibuchi
Masahiro Moriyama

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