Title:
光感受性基を有するβ-ベンジルオキシアスパラギン酸誘導体
Document Type and Number:
Japanese Patent JP4372751
Kind Code:
B2
Abstract:
The present invention relates to photosensitive derivatives of optically active L-threo-beta-benzyloxyaspartate or its benzene ring-substituted analogs, represented by the following formula (1) or (2): (1) (2) wherein R1 represents hydrogen atom, amino group, straight or branched lower aliphatic acylamino group optionally substituted at the acyl group portion, alicyclic acylamino group or aromatic acylamino group optionally having a substituent on the aromatic ring, R2 represents hydrogen atom or one or more straight or branched optionally substituted lower aliphatic alkyloxy groups on the benzene ring, R3 represents hydrogen atom, methyl group or carboxyl group, and R4 and R5 each represent hydrogen atom, hydroxyl group, straight or branched lower alkyloxy group optionally substituted at the alkyl portion, amino group, straight or branched lower alkyl-substituted amino group, or a halogen atom, which upon photoirradiation can produce compounds exhibiting a function of suppressing the glutamate uptake activity of L-glutamate transporters.
Inventors:
Keiko Shimamoto
Takaoka Kiyo
Takaoka Kiyo
Application Number:
JP2005500239A
Publication Date:
November 25, 2009
Filing Date:
May 30, 2003
Export Citation:
Assignee:
Suntory Holdings Limited
International Classes:
C07D311/16; A61K31/352; A61P25/08; A61P25/14; A61P25/28; C07C271/22; C07D311/18
Domestic Patent References:
| JP10130215A |
Foreign References:
| WO2003000698A1 |
Other References:
K. TAKAOKA, ET AL.,Synthesis and photoreactivity of cgaed blockers for glutamate transporters,BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS,2003年 3月10日,Vol.13,p.965-970
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Reiko Izumiya
Hisako Nozaki
Osamu Yamamoto
Mitsutoshi Nakamura
Shinobu Fukusho
Go Kajita
Naoshi Nakata
Yuki Ogasawara
Ryoko Oshikamo
Yamazaki Kosaku
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Hiroko Ejiri
Reiko Izumiya
Hisako Nozaki
Osamu Yamamoto
Mitsutoshi Nakamura
Shinobu Fukusho
Go Kajita
Naoshi Nakata
Yuki Ogasawara
Ryoko Oshikamo
Yamazaki Kosaku