Title:
BERBANE DERIVATIVE
Document Type and Number:
Japanese Patent JPS58185583
Kind Code:
A
Abstract:
Pharmaceutical compositions comprising racemic or optically active berbane derivatives of the general Formula VI wherein R<1> and R<2> each stands for an alkyl group having 1-4 carbon atoms or R<1> and R<2> together form a methylenedioxy group and pharmaceutically acceptable salts thereof. These derivatives have hypotensive activity, and the compounds in which R<1> and R<2> are C2-4 alkyl or methylenedioxy are new. The compounds of the general Formula VI are prepared by reacting a racemic or optically active compounds of the general Formula VII with trimethoxy-benzoic acid or a derivative - preferably a salt - thereof and isolating the compound of the general Formula VI thus obtained and if desired converting a base produced into a salt thereof or liberating the free base from a salt.
Inventors:
CHIYABA SAANTAI
RAJIYOSHIYU SABOO
ISHIYUTOBUAAN TOOTSU
RAASUROO SUEKERESHIYU
JIYUURA PATSUPU
EEBUA UDOBUARI
RAJIYOSHIYU SABOO
ISHIYUTOBUAAN TOOTSU
RAASUROO SUEKERESHIYU
JIYUURA PATSUPU
EEBUA UDOBUARI
Application Number:
JP5883683A
Publication Date:
October 29, 1983
Filing Date:
April 05, 1983
Export Citation:
Assignee:
CHINOIN GYOGYSZER ES VEGYESZET
International Classes:
A61K31/435; A61P9/12; C07D455/03; (IPC1-7): A61K31/435; C07D455/03
Attorney, Agent or Firm:
Matsuhiro Masahiro