Title:
BETA-ADRENALIN ACTIVE ANTAGONISTIC COMPOUND AND DERIVATIVES
Document Type and Number:
Japanese Patent JPS59176236
Kind Code:
A
Abstract:
Molecular structures of beta -adrenergic antagonists are modified to produce biologically active compounds. The beta -antagonists are modified to form molecules of the general structure: wherein R is most generally R sec -OCH2-, and in some instances is R sec -, and R sec = an aryl or substituted aryl moiety; R min = -H, -CH3, or a short chain alkyl moiety; and Y = -OH, or more usually, -OAX or -NHAX, where A = an alkyl, aryl, or aralkyl moiety, and X = a terminal grouping, such as -CH3, -CF3 or -(CH2)nCOOH; or AX may be a carrier moiety consisting of a defined peptide or protein.
Inventors:
MARII GUTSUDOMAN
DEBURA MARII-REIJII
ROBAATO PEDORO ROOZENKURANTSU
KENESU ROIDO MERUMON
MAIKERU SUTEFUAN BERURANDAA
DEBURA MARII-REIJII
ROBAATO PEDORO ROOZENKURANTSU
KENESU ROIDO MERUMON
MAIKERU SUTEFUAN BERURANDAA
Application Number:
JP1722284A
Publication Date:
October 05, 1984
Filing Date:
February 03, 1984
Export Citation:
Assignee:
UNIV CALIFORNIA
International Classes:
A61K31/165; A61K31/195; A61K31/22; A61K38/00; A61P25/02; C07C67/00; C07C227/00; C07C229/12; C07C235/74; C07C237/04; C07C237/06; C07C237/12; C07C237/22; C07C237/42; A61K31/16; C07C239/00; C07C275/38; C07D209/08; C07D209/48; C07D285/10; C07D303/22; C07D303/24; C07D405/12; C07K5/02; C07K5/065; (IPC1-7): A61K31/16; A61K31/195; A61K31/22; A61K31/40; A61K37/02; C07C101/12; C07C101/18; C07C103/22; C07C103/50; C07C127/19; C07D209/08; C07D209/48; C07D285/10; C07D303/20
Attorney, Agent or Firm:
Akihide Sugimura