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Title:
BETA-LACTAM DERIVATIVE
Document Type and Number:
Japanese Patent JPH0395156
Kind Code:
A
Abstract:

NEW MATERIAL: A compound of formula I (R1 is an amino having antibacterial activity; R2 is H, a lower alkoxy, a lower alkylthio, etc.; R3 is H or an organic group bonded via C, O, S or N; R4 is an electronegative acidic group, or R3 and R4 together form a heterocyclic ring; R5 is H, a lower alkyl, etc.) and its ester, salt, and hydrate.

EXAMPLE: [2S-(2α,5α,6β)]-6-[[[4-[1-ethyl-6-fluoro-1,4-dihydro-3-(methoxycarbonyl)-4- oxo-7quinolinyl]-1-piperazinyl]methylene]amino]-3,3-dimethyl-6-oxo-4-thia-1- azabicyclo[3,2,0]heptane-2-carboxylic acid.

USE: Treatment or prophylaxis of infectious diseases.

PROCESS: The compound of formula I can be obtained by reacting a compound of formula II or its ester with an acetal of formula R1-Rb (Rb is an acetal functional group) or its ester.


Inventors:
DENISU DORUTON KIISU
JIYON ROOSON ROBAATSU
CHIYUNNCHIEN UEI
Application Number:
JP19089690A
Publication Date:
April 19, 1991
Filing Date:
July 20, 1990
Export Citation:
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Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/397; A61K31/40; A61K31/43; A61K31/545; A61K31/546; A61P31/04; A61P31/12; C07D205/085; C07D205/095; C07D401/02; C07D401/12; C07D401/14; C07D499/00; C07D499/21; C07D501/00; C07D501/16; C07D501/59; C07D519/00; (IPC1-7): A61K31/40; A61K31/43; A61K31/545; C07D205/085; C07D205/095; C07D401/02; C07D401/12; C07D401/14; C07D499/02; C07D501/59
Attorney, Agent or Firm:
Heikichi Odashima



 
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