Title:
ベータ-ラクタマーゼ阻害剤プロドラッグ
Document Type and Number:
Japanese Patent JP2005539037
Kind Code:
A
Abstract:
Prodrugs of 6-beta-hydroxymethylpenicillanic acid sulfone having the structure wherein R is H or methyl, and solvates thereof, are disclosed. Also disclosed are pharmaceutical compositions comprising a prodrug of the present invention or a solvate thereof, an optional beta-lactam antibiotic and a pharmaceutically acceptable excipient. Further disclosed is a method for increasing the therapeutic effectiveness of a beta-lactam antibiotic in a mammal by administering an effective amount of a beta-lactam antibiotic and an effectiveness-increasing amount of a prodrug of the present invention, or a solvate thereof. Additionally disclosed is a method for treating a bacterial infection in a mammal by administering a therapeutically effective amount of a pharmaceutical composition of the present invention to a mammal in need thereof.
Inventors:
Antony Mafat
Dale Gordon MacLeod
Dale Gordon MacLeod
Application Number:
JP2004530453A
Publication Date:
December 22, 2005
Filing Date:
August 11, 2003
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D499/861; A61K31/43; A61P31/04; A61P43/00; C07D499/00; C07D499/48; C07D499/86; C07D499/897; C07D; (IPC1-7): C07D499/86; A61K31/43; A61P31/04; A61P43/00; C07D499/861
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa