Title:
BETAALACTAM DERIVATIVE*ITS MANUFACTURE AND MEDICAL COMPOSITION CONTAINING IT
Document Type and Number:
Japanese Patent JPS5511572
Kind Code:
A
Abstract:
The invention relates to a process for the preparation of beta -lactam derivatives having a substituted hydroxymethyl group at the carbon atom alpha to the lactam carbonyl group, to the novel antibacterially-active derivatives so-obtainable and to pharmaceutical compositions containing these.
The process comprises reacting under specified conditions an alpha -halo- beta -lactam starting material with activated zinc in the presence of an appropriate aldehyde or ketone and hydrolysing the resulting zinc complex.
The novel beta -lactam derivatives are of the general formula I
(with the meaning of R, R1-R4, Y and Z as given in the specification) and include the pharmaceutically acceptable salts thereof.
Inventors:
ASHITSUTO KUMAA GANGURII
BIYOORU MUUPIRU GIRIJIYABARABU
PATORISHIA RII KABENDAA
ORUGA SAARU
SUCHIYUAATO UORUTAA MATSUKONBI
BIYOORU MUUPIRU GIRIJIYABARABU
PATORISHIA RII KABENDAA
ORUGA SAARU
SUCHIYUAATO UORUTAA MATSUKONBI
Application Number:
JP6875079A
Publication Date:
January 26, 1980
Filing Date:
June 01, 1979
Export Citation:
Assignee:
SCHERICO LTD
International Classes:
A61K31/43; A61K31/545; A61P31/04; C07D205/08; C07D463/00; C07D477/02; C07D501/00; C07D477/10; C07D487/04; C07D499/00; C07D499/04; C07D499/86; C07D499/861; C07D499/87; C07D499/897; C07D501/04; C07D503/00; C07D505/00; (IPC1-7): A61K31/43; A61K31/545; C07D499/00; C07D499/04; C07D501/00; C07D501/04