BIARYL PDE4 INHIBITOR FOR TREATING LUNG DISEASES AND CARDIOVASCULAR DISEASES

Japanese Patent JP2015044829

A

PROBLEM TO BE SOLVED: To provide a compound having biaryl phosphodiesterase-4 (PDE4) inhibitory action useful for treatment and prevention of stroke, myocardial infraction and cardiovascular inflammatory diseases.SOLUTION: There is provided a biaryl compound having at least one further ring represented by following formula. In the formula, Ris a phenyl group, a 5-membered heteroaryl group, a 6-membered heteroaryl group or the like; Ris -COOH, -OH, -NHC(=O)NHCHCOOEt or the like ;Ris H, a halogen atom, a nitro group, an acyl group or the like ;Ris H or F ;Ris H, -C(=O)NH, -(C1-C6)alkyl or the like; Ris H, a halogen atom, -OH, a (C1-C6)alkyl group or the like; Ris H, a (C1-C6)alkyl group or a halogen atom; and M is a direct bond, a methylene group or the like.

WO/1992/004311

NEW LEUKOTRIENE-B¿4? ANTAGONISTS, PROCESS FOR PRODUCING THE SAME AND THEIR USE AS MEDICINAL DRUGS

JASBIR SINGH
MARK GURNEY
ALEX BURGIN
ALEXANDER KISELYOV
MUNAGALA RAO
TIMOTHY HAGEN

JP2014209336A

March 12, 2015

October 10, 2014

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DECODE GENETICS EHF

C07C65/40; A61K31/17; A61K31/18; A61K31/192; A61K31/197; A61K31/216; A61K31/401; A61K31/415; A61K31/4164; A61K31/428; A61K31/433; A61K31/437; A61K31/44; A61K31/4412; A61K31/4439; A61K31/4545; A61K31/505; A61K31/506; A61K31/52; A61K31/522; A61K45/00; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/10; A61P19/08; A61P29/00; A61P35/00; A61P43/00; C07C69/76; C07C275/32; C07C275/62; C07C307/10; C07D207/16; C07D213/40; C07D213/64; C07D213/74; C07D213/75; C07D213/76; C07D213/79; C07D213/89; C07D231/12; C07D233/64; C07D233/90; C07D239/42; C07D275/06; C07D285/135; C07D401/04; C07D401/06; C07D403/04; C07D471/04; C07D473/18; C07D473/40

Ken-ichi Morita
Kenjiro Yamaguchi

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