Title:
ビアリール尿素誘導体またはそれらの塩、およびそれらの調製方法および使用
Document Type and Number:
Japanese Patent JP7092356
Kind Code:
B2
Abstract:
The present invention discloses a biaryl urea ROR³t inhibitor, and specifically relates to a biaryl urea derivative, as represented by formula I, with an ROR³t inhibiting activity, and a preparation process thereof, and a pharmaceutical composition comprising the compound. Further disclosed is use of the compound for treating an ROR³t-related disease.
Inventors:
One, Yong Fei
Fan, yafei
You, fuzzy
Tan, Tin
Fan, yafei
You, fuzzy
Tan, Tin
Application Number:
JP2018567278A
Publication Date:
June 28, 2022
Filing Date:
June 19, 2017
Export Citation:
Assignee:
Fudan University
International Classes:
C07C317/14; A61K31/17; A61K31/18; A61K31/195; A61K31/277; A61K31/415; A61K31/44; A61P1/04; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P37/06; A61P43/00; C07C275/28; C07C275/30; C07C311/03; C07C311/08; C07C311/16; C07C311/17; C07C381/10; C07D213/55; C07D213/70; C07D213/71; C07D231/12
Domestic Patent References:
| JP2006507329A | ||||
| JP2005538152A | ||||
| JP2007537272A |
Foreign References:
| WO2013029338A1 | ||||
| WO2015101928A1 | ||||
| WO1997029743A1 | ||||
| WO2012021963A1 | ||||
| WO1999038846A1 | ||||
| WO2003000245A1 | ||||
| WO2010113022A1 | ||||
| WO2011025965A1 |
Other References:
REGISTRY(STN)[online],掲載日:2016年5月6日以前,検索日:2021年3月25日,CAS登録番号1904954-76-2, 1901278-91-8, 1647447-27-5
REGISTRY(STN)[online],掲載日:2007年4月13日,検索日:2021年3月25日,CAS登録番号930033-27-5
REGISTRY(STN)[online],掲載日:2012年8月8日,検索日:2021年4月5日,CAS登録番号1388209-34-4
REGISTRY(STN)[online],掲載日:2014年9月18日,検索日:2021年4月5日,CAS登録番号1623369-31-2
WANG, Y. et al.,Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors,ACS Medicinal Chemistry Letters,2015年,6(7),pp. 787-792
TARKO, L. et al.,QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII,Bioorganic & Medicinal Chemistry,2013年,21(6),pp. 1404-1409
WINUM, J. et al.,Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines,Bioorganic & Medicinal Chemistry Letters,2012年,22(14),pp. 4681-4685
POTKIN, V. I. et al.,The Synthesis of Isoxazolyl- and Isothiazolylcarbamides Exhibiting Antitumor Activity,Russian Journal of Organic Chemistry,2014年,50(11),pp. 1667-1676
REGISTRY(STN)[online],掲載日:2007年4月13日,検索日:2021年3月25日,CAS登録番号930033-27-5
REGISTRY(STN)[online],掲載日:2012年8月8日,検索日:2021年4月5日,CAS登録番号1388209-34-4
REGISTRY(STN)[online],掲載日:2014年9月18日,検索日:2021年4月5日,CAS登録番号1623369-31-2
WANG, Y. et al.,Discovery of Biaryl Amides as Potent, Orally Bioavailable, and CNS Penetrant RORγt Inhibitors,ACS Medicinal Chemistry Letters,2015年,6(7),pp. 787-792
TARKO, L. et al.,QSAR studies of sulfamate and sulfamide inhibitors targeting human carbonic anhydrase isozymes I, II, IX and XII,Bioorganic & Medicinal Chemistry,2013年,21(6),pp. 1404-1409
WINUM, J. et al.,Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines,Bioorganic & Medicinal Chemistry Letters,2012年,22(14),pp. 4681-4685
POTKIN, V. I. et al.,The Synthesis of Isoxazolyl- and Isothiazolylcarbamides Exhibiting Antitumor Activity,Russian Journal of Organic Chemistry,2014年,50(11),pp. 1667-1676
Attorney, Agent or Firm:
Aiko Patent Office, a patent business corporation