Title:
BICYCLIC BENZO CONDENSATION COMPOUND AND COMPOSITION
Document Type and Number:
Japanese Patent JPS58180456
Kind Code:
A
Abstract:
Bicyclic fused benzenoid compounds of the formulaand pharmaceutically acceptable cationic and acid addition salts thereof, where M is O, CH2 or NR6; R6 is hydrogen, formyl, carbobenzyloxy or certain carboalkoxyalkyl, alkanoyl, alkyl, aralkyl or aralkylcarbonyl groups;A' is:(1) A where one of A and B is hydrogen such that when A is hydrogen, B is C(R2R3) (CH2)fO and f is 1 or 2; when B is hydrogen, A is C(R2R3)(CH2)fO and f is 0 or 1, when taken together A and OR1 form a lactone or certain derivatives thereof;(2) A' is HOCH2CONR12R13;(3) A' is 03;O is CO2R7, CORe, C(OH)R8R9, CN, CONR12R13, CH2NR12R13, CH2NHCOR14, CH2NHSO2R17 or 5-tatrazoyl;03 is spiro -5-tetrazolyl, CH2CONHCOR7, COOH or certain ester, amide, carboximido or sulfonimido derivatives thereof, CONHOH, CONHCONH2, or COCH2O4 where O4 is CN or COOH or certain esters thereof;R1 is hydrogen, benzyl or certain acyl groups; R4 is hydrogen, certain alkyl or certain aralkyl groups; R5 is hydrogen or certain alkyl groups; Z is (C1-C9)alkylene, optionally interrupted by O, S, SO or S02; and W is hydrogen, methyl, certain aryl or cycloalkyl groups; useful in mammals as analgesics, tranquilizers, antiemetic agents, diuretics, anticonvulsants, antidiarrheals, antitussives, in treatment of glaucoma, and intermediates therefore.
Inventors:
JIEEMUZU FUREDERITSUKU ETSUGUR
MAIKERU ROSU JIYONSON
ROORENSU SHIYAAMAN MERUBUIN JI
MAIKERU ROSU JIYONSON
ROORENSU SHIYAAMAN MERUBUIN JI
Application Number:
JP4253983A
Publication Date:
October 21, 1983
Filing Date:
March 16, 1983
Export Citation:
Assignee:
PFIZER
International Classes:
C07C69/157; A61K31/05; A61K31/085; A61K31/165; A61K31/19; A61K31/215; A61K31/35; A61K31/352; A61K31/353; A61K31/425; A61K31/44; A61K31/443; A61P1/08; A61P1/12; A61P25/04; A61P29/00; C07C43/23; C07C61/39; C07C67/00; C07C69/738; C07C233/16; C07C233/18; C07C235/32; C07C235/34; C07C253/00; C07C255/40; C07C275/50; C07D311/04; C07D311/22; C07D311/58; C07D405/12; C07D407/12; C07D413/12; C07D417/12; C07D491/10; C07D491/20; C07D493/06; C07D493/10; (IPC1-7): C07C69/157; A61K31/35; A61K31/425; A61K31/44; C07C69/738; C07C79/26; C07C103/26; C07C103/38; C07C103/80; C07C121/76; C07C127/22; C07D311/22; C07D311/58; C07D405/12; C07D417/12; C07D491/107; C07D493/06
Domestic Patent References:
| JPS49116069A | 1974-11-06 | |||
| JPS4742766A |
Attorney, Agent or Firm:
Kyozo Yuasa
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