Title:
標的基質の選択的修飾のための二官能性分子
Document Type and Number:
Japanese Patent JP2024513566
Kind Code:
A
Abstract:
本開示は二官能性化学的コンジュゲーション分子に関し、これは標的基質の修飾剤としての有用性が見出される。本開示は酵素結合部分、化学リンカー部分及び標的結合部分を含む多官能性化合物を含み、これは求電子性反応基を更に含んでいてもよい。本発明に記載の分子は基質の修飾、例えば、翻訳後修飾を、酵素の天然基質ではないタンパク質に対して行う使用を見出す。疾患又は障害は本開示の分子により処置又は予防され得る。
Inventors:
Chowdhury Amit
Shoba Veronica
Deb Algia
Nguyen Tuan
Ray Sophia
Munkanatta Godage Danushka
Tiwari Praveen
model ashley
siriwardena sacini
Shoba Veronica
Deb Algia
Nguyen Tuan
Ray Sophia
Munkanatta Godage Danushka
Tiwari Praveen
model ashley
siriwardena sacini
Application Number:
JP2023561654A
Publication Date:
March 26, 2024
Filing Date:
April 08, 2022
Export Citation:
Assignee:
The Broad Institute Incorporated
The Brigham And Women's Hospital Incorporated
The Brigham And Women's Hospital Incorporated
International Classes:
A61K47/54; A61K31/519; A61K31/5513; A61K31/5517; A61K47/62; A61P31/04; A61P31/06; A61P31/10; A61P31/12; A61P33/00; A61P35/00; A61P43/00; C07D243/06; C07D403/12; C07D487/04; C07D495/14; C07D519/00
Attorney, Agent or Firm:
Sykes Patent Attorney Corporation
Previous Patent: Synthesis of rapamycin analog compounds
Next Patent: Bioactive compositions based on 1-methylxanthines and methods of using them
Next Patent: Bioactive compositions based on 1-methylxanthines and methods of using them