Title:
Bile acid reuse inhibitor for the disposal of high bile Bleeding and bile Stagnation liver disease
Document Type and Number:
Japanese Patent JP6217939
Kind Code:
B2
Abstract:
Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.
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Inventors:
Gedulin, Bronislava
Grey, michael
O'Donnell, Niall
Grey, michael
O'Donnell, Niall
Application Number:
JP2014539093A
Publication Date:
October 25, 2017
Filing Date:
October 26, 2012
Export Citation:
Assignee:
Lumena Pharmaceuticals LLC
International Classes:
A61K31/4995; A61K31/38; A61K31/575; A61K45/00; A61P1/16; A61P17/04
Domestic Patent References:
| JP4497472B2 | ||||
| JP4711953B2 | ||||
| JP2002542208A | ||||
| JP2014532662A |
Foreign References:
| WO2012064266A1 | ||||
| WO2010062861A1 |
Other References:
Journal of Medicinal Chemistry,2005年,Vol.48, No.18,p.5853-5868
Attorney, Agent or Firm:
Kazuhiro Kiyohara