Title:
胆汁由来免疫調節組成物
Document Type and Number:
Japanese Patent JP4708511
Kind Code:
B2
Abstract:
The present invention relates to a composition for use as an immunomodulator comprising small molecular weight components of less than 3000 daltons, and having the following properties: a) is extractable from bile of animals; b) is capable of stimulating monocytes and macrophages in vitro; c) is capable of modulating tumor necrosis factor production; d) contains no measurable IL-1a, IL-1b, TNF, IL-6, IL-8, IL-4, GM-CSF or IFN-gamma; e) has an anti-proliferative effect in a malignant mouse hybridoma cell line; f) shows no cytotoxicity to human peripheral blood mononuclear cells; and g) is not an endotoxin. The invention also relates to a method of preparing the composition and its use an immunomodulator.
Inventors:
Lang, romeo
Application Number:
JP50837095A
Publication Date:
June 22, 2011
Filing Date:
September 09, 1994
Export Citation:
Assignee:
Erin Mills Biotech Incorporated
International Classes:
A61K38/00; A61K45/00; A61K31/01; A61K31/07; A61K31/08; A61K31/13; A61K31/185; A61K31/195; A61K31/20; A61K31/215; A61K31/56; A61K31/575; A61K31/685; A61K31/70; A61K31/715; A61K35/413; A61K38/01; A61K38/17; A61K45/06; A61P35/00; A61P37/00; C07K14/47
Domestic Patent References:
| JP551319A | ||||
| JP680572A | ||||
| JP5279259A | ||||
| JP4159221A |
Other References:
MOL.CELL.BIOL.,(1990),10(4),P.1498-1506
CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY,(1989),3(3),P.236-240
CLINICAL AND INVESTIGATIVE MEDICINE,SUPPL.,(1992),15(4),P.A89 546項
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,SUPPL.,(1990),116(1),P.51 A1.240.01項
HEPATOLOGY,(1989),10(4),P.454-458
HEPATOLOGY,(1992),16(3),P.719-723
HEPATOLOGY,(1992),16(2),P.358-364
JPN.J.CANCER RES.,(1987),78,P.32-39
CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY,(1989),3(3),P.236-240
CLINICAL AND INVESTIGATIVE MEDICINE,SUPPL.,(1992),15(4),P.A89 546項
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,SUPPL.,(1990),116(1),P.51 A1.240.01項
HEPATOLOGY,(1989),10(4),P.454-458
HEPATOLOGY,(1992),16(3),P.719-723
HEPATOLOGY,(1992),16(2),P.358-364
JPN.J.CANCER RES.,(1987),78,P.32-39
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Toshitaka Tsurugi
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Takumi Terachi
Toshitaka Tsurugi