Title:
BINDING AGENTS BINDING TO PD-L1 AND CD137 AND USE THEREOF
Document Type and Number:
Japanese Patent JP2023100942
Kind Code:
A
Abstract:
To provide bispecific antibodies which block PD1-(PD-L1) inhibitory signaling and, at the same time, co-stimulate T cells via trans binding to the CD137 molecules expressed on activated T cells, with activation to occur through the trans binding.SOLUTION: The invention discloses bispecific antibodies binding to human PD-L1 and also binding to human CD137. The invention further discloses uses of the antibodies of the invention and methods, nucleic acid constructs and host cells for producing antibodies of the invention.SELECTED DRAWING: None
Inventors:
ISIL ALTINTAS
SATIJN DAVID
RIK RADEMAKER
PAUL PERREN
UGUR SAHIN
FRIEDERIKE GIESEKE
ALEXANDER MUIK
CHRISTIAN GRUNWITZ
EDWARD VAN DEN BRINK
DENNIS VERZIJL
SATIJN DAVID
RIK RADEMAKER
PAUL PERREN
UGUR SAHIN
FRIEDERIKE GIESEKE
ALEXANDER MUIK
CHRISTIAN GRUNWITZ
EDWARD VAN DEN BRINK
DENNIS VERZIJL
Application Number:
JP2023078308A
Publication Date:
July 19, 2023
Filing Date:
May 11, 2023
Export Citation:
Assignee:
GENMAB AS
BIONTECH SE
BIONTECH SE
International Classes:
C12N15/13; A61K35/12; A61K35/76; A61K39/395; A61K45/00; A61K48/00; A61P11/00; A61P35/00; A61P43/00; C07K16/28; C07K16/42; C07K16/46; C12N5/10; C12N15/63; C12P21/08
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto