BINDING MEMBERS AGAINST IL-1R1

Title:

BINDING MEMBERS AGAINST IL-1R1

Document Type and Number:

Japanese Patent JP2016006050

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide binding members, especially antibody molecules, specific for interleukin 1 receptor 1 (IL-1R1).SOLUTION: Isolated binding members specific for IL-1R1 which competes with IL-I and IL-1Ra for binding to IL-1R1 and binds IL-1R1 with a Kof 10 pM or less when measured by Kinexa. The binding members are useful for, inter alia, treatment of disorders mediated by IL-1R1 including rheumatoid arthritis, asthma and chronic obstructive pulmonary disease (COPD).

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Inventors:

JAMIE IAIN CAMPBELL
DUNCAN JAMES COCHRANE
SIMON CHARLES CRUWYS
DONNA KIRSTY FINCH
MARIA ANASTASIA TERESA GROVES
DAVID CHRISTOPHER LOWE

Application Number:

JP2015132611A

Publication Date:

January 14, 2016

Filing Date:

July 01, 2015

Export Citation:

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Assignee:

MEDIMMUNE LTD

International Classes:

C07K16/28; A61K39/395; A61P3/10; A61P9/10; A61P11/00; A61P11/06; A61P19/02; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P35/02; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12P21/08

Domestic Patent References:

JP2006517179A	2006-07-20
JP2007527230A	2007-09-27

Foreign References:

WO2007063311A2

2007-06-07

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

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