Title:
生理活性で、ナノカプセル化された抗酸化物質の送達
Document Type and Number:
Japanese Patent JP6668327
Kind Code:
B2
Abstract:
Methods and compositions are disclosed for delivering lutein or other antioxidant to target tissues such as the eye, in bioactive form, while protecting the antioxidant from degradation. The antioxidant is encapsulated in nanoparticles comprising a protein such as zein or a polymer such as poly(lactic-co-glycolic acid) (PLGA). Preferably a surfactant is associated with the nanoparticles as well, further helping to protect the antioxidant. After the nanoparticles are administered to the target tissue, bioactive antioxidant is released to the tissue over time. Optionally, the nanoparticles are admixed with a thermosensitive, bioadhesive gel to promote slow release of antioxidant. The methods and compositions are useful for treating or preventing conditions such as age-related macular degeneration or cataracts.
Inventors:
Sabrioff, Christina M.
Astate, Carlos Y.
Bodoki, ede
Bustinal, oliview
Samoria, Obijoux Cyprien
Dinte, Elena
Astate, Carlos Y.
Bodoki, ede
Bustinal, oliview
Samoria, Obijoux Cyprien
Dinte, Elena
Application Number:
JP2017505869A
Publication Date:
March 18, 2020
Filing Date:
August 10, 2015
Export Citation:
Assignee:
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY AND AGRICULTURAL AND MECHANICAL COLLEGE
IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY
IULIU HATIEGANU UNIVERSITY OF MEDICINE AND PHARMACY
International Classes:
A61K31/047; A61K9/06; A61K31/01; A61K31/015; A61K31/07; A61K47/34; A61P27/02; A61P27/12
Domestic Patent References:
| JP2014515007A | ||||
| JP2004514731A | ||||
| JP2300114A | ||||
| JP2003292459A | ||||
| JP2009515821A |
Attorney, Agent or Firm:
Makoto Onda
Hironobu Onda
Atsushi Honda
Miki Nakamura
Hironobu Onda
Atsushi Honda
Miki Nakamura