Title:
活性剤の送達のための生分解性脂質
Document Type and Number:
Japanese Patent JP6409011
Kind Code:
B2
Abstract:
The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.
Inventors:
Mutiah Manoharan
Martin Mayer
Muthu Sammy Jayaraman
Shigeo Matsuda
Narayananan Naile Kay Jayapurakash
Callantottil, Gee Rajiv
Akin Akink
Thomas A. Byley
Martin Mayer
Muthu Sammy Jayaraman
Shigeo Matsuda
Narayananan Naile Kay Jayapurakash
Callantottil, Gee Rajiv
Akin Akink
Thomas A. Byley
Application Number:
JP2016031867A
Publication Date:
October 17, 2018
Filing Date:
February 23, 2016
Export Citation:
Assignee:
Alniram Pharmaceuticals Incorporated
International Classes:
C07C229/12; A61K31/7088; A61K47/18; A61K48/00
Domestic Patent References:
| JP9301936A | ||||
| JP9278726A | ||||
| JP9110814A | ||||
| JP5506661A | ||||
| JP5893611B2 | ||||
| JP2011509258A |
Foreign References:
| WO1994019314A1 | ||||
| WO1994018987A1 | ||||
| FR2909378A1 | ||||
| WO2010054401A1 | ||||
| WO2010054405A1 |
Other References:
Biophysical Chemistry ,2007年,129(2-3),p.137-147
Chemistry and Physics of Lipids ,2003年,124(1),p.49-61
Bioorganic & Medicinal Chemistry ,2001年,9(2),p.245-254
Chemistry and Physics of Lipids ,2003年,124(1),p.49-61
Bioorganic & Medicinal Chemistry ,2001年,9(2),p.245-254
Attorney, Agent or Firm:
Yasuhiko Murayama
Shinya Mitsuhiro
Shinya Mitsuhiro