Title:
生分解性ポリ(β-アミノエステル)およびその使用
Document Type and Number:
Japanese Patent JP4740864
Kind Code:
B2
Abstract:
Poly(²-amino esters) prepared from the conjugate addition of bis(secondary amines) or primary amines to a bis(acrylate ester) are described. Methods of preparing these polymers from commercially available starting materials are also provided. These tertiary amine-containing polymers are preferably biodegradable and biocompatible and may be used in a variety of drug delivery systems. Given the poly(amine) nature of these polymers, they are particularly suited for the delivery of polynucleotides. Nanoparticles containing polymer/polynucleotide complexes have been prepared. The inventive polymers may also be used to encapsulate other agents to be delivered. They are particularly useful in delivering labile agents given their ability to buffer the pH of their surroundings. A system for preparing and screening polymers in parallel using semi-automated robotic fluid delivery systems is also provided.
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Inventors:
Robert the Ranger
Lynn, David M.
Anderson, Daniel G.
Akin, Akin
Lynn, David M.
Anderson, Daniel G.
Akin, Akin
Application Number:
JP2006533421A
Publication Date:
August 03, 2011
Filing Date:
May 26, 2004
Export Citation:
Assignee:
Massachusetts Institute of Technology
International Classes:
C08G73/00; G01N33/50; A61K9/50; A61K9/51; A61K9/56; A61K9/58; A61K38/00; A61K39/00; A61K45/00; A61K47/18; A61K47/22; A61K47/34; A61K47/48; A61K48/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; C07D207/08; C07D211/26; C07D233/02; C07D233/04; C07D233/61; C07D295/12; C08G63/40; C08G63/685; C08G69/44; C08G73/02; C08G73/06; C08G85/00; C08L67/02; C08L79/00; C08L101/16; C12N15/09; C12N15/88; G01N33/15; C08L67/04; C08L77/04; C08L79/02; C08L89/00; C08L99/00
Foreign References:
| WO2002031025A1 |
Other References:
AKINC,A. et al,Parallel Synthesis and Biophysical Characterization of a Degradable Polymer Library for Gene Delivery,Journal of the American Chemical Society,2003年,Vol.125, No.18,p.5316-5323
LYNN,D.M. et al,Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA,Journal of the American Chemical Society,2000年,Vol.122, No.44,p.10761-10768
LYNN,D.M. et al,Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library,Journal of the American Chemical Society,2001年,Vol.123, No.33,p.8155-8156
VAZQUEZ,E. et al,Construction of Hydrolytically-Degradable Thin Films via Layer-by-Layer Deposition of Degradable Polyelectrolytes,Journal of the American Chemical Society,2002年,Vol.124, No.47,p.13992-13993
LYNN,D.M. et al,Degradable Poly(β-amino esters): Synthesis, Characterization, and Self-Assembly with Plasmid DNA,Journal of the American Chemical Society,2000年,Vol.122, No.44,p.10761-10768
LYNN,D.M. et al,Accelerated Discovery of Synthetic Transfection Vectors: Parallel Synthesis and Screening of a Degradable Polymer Library,Journal of the American Chemical Society,2001年,Vol.123, No.33,p.8155-8156
VAZQUEZ,E. et al,Construction of Hydrolytically-Degradable Thin Films via Layer-by-Layer Deposition of Degradable Polyelectrolytes,Journal of the American Chemical Society,2002年,Vol.124, No.47,p.13992-13993
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita