Title:
発現プロファイリングを用いるバイオ均等性の決定
Document Type and Number:
Japanese Patent JP2006506046
Kind Code:
A
Abstract:
The present invention provides methods to use expression profiles to determine the bioequivalence of two or more pharmaceutically equivalent drug formulations. In addition, this invention provides methods to select drug formulations that are able to substitute for standard drug formulations without change in clinical efficacy. In other embodiments, this invention provides computer systems, kits and databases for carrying out the methods of the invention.
Inventors:
Marlene Michel Dressman
Christian Nikola Lovedan
Lee Ann McLean
Michael Fristos Polymeropulos
Christian Nikola Lovedan
Lee Ann McLean
Michael Fristos Polymeropulos
Application Number:
JP2004501639A
Publication Date:
February 23, 2006
Filing Date:
April 30, 2003
Export Citation:
Assignee:
NOVARTIS AG
International Classes:
C12Q1/68; A01N43/02; A61K9/22; A61K31/335; A61K38/00; A61P17/04; A61P17/06; A61P29/00; A61P37/06; A61P37/08; C12N15/09; C12Q1/02; G01N27/447; G01N30/02; G01N33/15; G01N33/50; G01N33/53; G01N33/543; G01N37/00; G05D7/00; G05D11/00; G06F19/00; A61K9/20; A61K31/439
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima