Title:
インスリン様増殖因子1受容体キナーゼ阻害剤に対する抗癌反応の予測に役立つ生物学的マーカー
Document Type and Number:
Japanese Patent JP2013527748
Kind Code:
A
Abstract:
The present invention provides diagnostic methods for predicting the effectiveness of treatment of a cancer patient with an IGF-1R kinase inhibitor that inhibits both IGF-1R and IR kinases. Methods are provided for identifying patients with cancer who are likely to benefit from treatment with an IGF-1R kinase inhibitor that inhibits both IGF-1R and IR kinases. Methods are also provided for identifying patients with cancer who are likely to benefit from treatment with an IGF-1R kinase inhibitor that inhibits both IGF-1R and IR kinases, but who would likely not respond to therapy with an anti-IGF-1R antibody. Methods are also provided for identifying patients with cancer who are more likely to benefit from treatment with anti-IGF-1R antibody. Improved methods for treating cancer patients with IGF-1R kinase inhibitors that incorporate these methods are also provided.
Inventors:
Back, elizabeth a
Epstein, David M
Migrase, Mark Earl
Epstein, David M
Migrase, Mark Earl
Application Number:
JP2012556232A
Publication Date:
July 04, 2013
Filing Date:
March 03, 2011
Export Citation:
Assignee:
OSI Pharmaceuticals, LRC
International Classes:
C12Q1/68; A61K45/00; A61K45/06; A61P35/00; A61P43/00; C12N15/09; C12Q1/02; G01N33/50; G01N33/574
Foreign References:
| WO2010048123A2 | 2010-04-29 | |||
| WO2008108986A2 | 2008-09-12 |
Other References:
JPN6015016218; Ｔ．Ｍ．Ｐｉｔｔｓ， ｅｔ ａｌ．， Ｃｌｉｎ Ｃａｎｃｅｒ Ｒｅｓ， １６（１２）， ｐｐ３１９３-３２０４
JPN7015001074; Ａ．Ｗ．Ｔｏｌｃｈｅｒ， ｅｔ ａｌ．， Ｊ Ｃｌｉｎ Ｏｎｃｏｌｏｇｙ， ２００７， ２５（１８Ｓ）， ｐ３００２， Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ｔｈｅ Ｉｎｔｅｒｎｅｔ＜ＵＲＬ： ｈｔｔｐ：／／
JPN7015001074; Ａ．Ｗ．Ｔｏｌｃｈｅｒ， ｅｔ ａｌ．， Ｊ Ｃｌｉｎ Ｏｎｃｏｌｏｇｙ， ２００７， ２５（１８Ｓ）， ｐ３００２， Ｒｅｔｒｉｅｖｅｄ ｆｒｏｍ ｔｈｅ Ｉｎｔｅｒｎｅｔ＜ＵＲＬ： ｈｔｔｐ：／／
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama
Yasushi Kobayashi
Hiroyuki Tomita
Osamu Hoshino
Akiko Nakahama