Title:
BIOLOGICAL NANOPORES FOR BIOPOLYMER SENSING AND SEQUENCING BASED ON FRAC ACTINOPORIN
Document Type and Number:
Japanese Patent JP2022064983
Kind Code:
A
Abstract:
To provide nanopores and the use thereof in various applications, such as analysis of biopolymers and macromolecules, by making electrical measurements during translocation through nanopores.SOLUTION: Provided is a system comprising a funnel-shaped proteinaceous nanopore comprising an α-helical pore-forming toxin that is a member from the actinoporin protein family. In the system, the α-helical pore-forming toxin is Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.SELECTED DRAWING: None
Inventors:
GIOVANNI MAGLIA
CARSTEN WLOKA
NATALIE LISA MUTTER
MISHA SOSKINE
HUANG GANG
CARSTEN WLOKA
NATALIE LISA MUTTER
MISHA SOSKINE
HUANG GANG
Application Number:
JP2022014867A
Publication Date:
April 26, 2022
Filing Date:
February 02, 2022
Export Citation:
Assignee:
UNIV GRONINGEN
International Classes:
C12Q1/6869; C07K14/435; C07K17/02; G01N27/00
Domestic Patent References:
| JP2013540423A | 2013-11-07 |
Foreign References:
| US20120055792A1 | 2012-03-08 |
Other References:
KOJI TANAKA, NATURE COMMUNICATIONS, vol. 6, JPN6021017909, 2015, pages 6337, ISSN: 0004978496
BIOCHIMIE, vol. 116, JPN6023002624, 2015, pages 70 - 78, ISSN: 0004978497
BIOCHIMIE, vol. 116, JPN6023002624, 2015, pages 70 - 78, ISSN: 0004978497
Attorney, Agent or Firm:
Satoshi Murakoshi
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