Title:
生物学的物質及びその使用
Document Type and Number:
Japanese Patent JP2007515161
Kind Code:
A
Abstract:
The invention provides a method for identifying and/or making compounds for use in reducing and/or preventing fibrosis, comprising the steps: providing a cell type capable of expressing TIEG and/or Smad-7; providing a test compound; providing an amount of CTGF or a functional equivalent thereof, exposing the cell type to the test compound; subsequently or simultaneously exposing the cell type to the CTGF or functional equivalent thereof; detecting and/or measuring the expression of Smad-7 and TIEG; and comparing the amount of Smad-7 and/or TIEG expressed in the presence of the test compound with the amount of Smad-7 and/or TIEG produced detected and/or measured in the absence of a test compound; determining if a compound reduces and/or prevents fibrosis on the basis that it causes no change or an increase in Smad-7 expression and/or no change or a decrease in TIEG expression. There is also provided compounds for reducing and/or preventing fibrosis and uses of such compounds.
Inventors:
Nadia Abdul Wahab
Roger Maxwell Mason
Roger Maxwell Mason
Application Number:
JP2006540575A
Publication Date:
June 14, 2007
Filing Date:
November 12, 2004
Export Citation:
Assignee:
Imperial Innovations Limited
International Classes:
C12Q1/68; A61K31/7088; A61K38/00; A61K39/00; A61K39/395; A61K48/00; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P21/00; A61P27/02; C12N15/09; C12Q1/02; G01N33/15; G01N33/50; G01N33/74
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro