Title:
インビボおよび/またはインビトロ安定性が増大した生物学的に活性なタンパク質
Document Type and Number:
Japanese Patent JP5351889
Kind Code:
B2
Abstract:
The present invention relates to biologically active proteins comprising at least two domains wherein a first domain of said at least two domains comprises an amino acid sequence having and/or mediating said biological activity and a second domain of said at least two domains comprises an amino acid sequence consisting preferably of at least about 100 amino acid residues forming a random coil conformation whereby said random coil conformation mediates an increased in vivo and/or in vitro stability of said biologically active protein. Furthermore, nucleic acid molecules encoding the inventive biologically active proteins and vectors and cells comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions comprising the compounds of the invention as well as for specific uses of the biologically active proteins, nucleic acid molecules, vectors and cells of the invention.
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Inventors:
Scaler, candy
Seeobold, Ina
Sherpancy, Martin
Seeobold, Ina
Sherpancy, Martin
Application Number:
JP2010512606A
Publication Date:
November 27, 2013
Filing Date:
June 20, 2008
Export Citation:
Assignee:
Technische Universit Munich
International Classes:
C12N15/09; A61K38/00; A61K38/21; A61K38/22; A61K38/27; A61K38/46; A61K39/395; C07K14/475; C07K14/52; C07K14/575; C07K16/00; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10
Foreign References:
| US5677172 | ||||
| WO2006126102A1 |
Other References:
JOURNAL OF PEPTIDE RESEARCH,2003年11月,Vol.62, No.5,pp.214-226
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Norio Omori
Takayuki Imazato
Yasuhito Suzuki
Eiji Katayama
Norio Omori
Takayuki Imazato
Yasuhito Suzuki