Title:
バイオマーカー検出
Document Type and Number:
Japanese Patent JP2011511930
Kind Code:
A
Abstract:
Provided are methods, compositions and articles of manufacture for detecting biomarkers indicative of exposure of a mammal to organophosphate compounds. The organophosphate compound includes pesticides, their metabolites and highly reactive organophosphoryl compounds. In one aspect of the invention, the biomarker results from interaction of the organophosphate compound with a polypeptide such as a serine hydrolase that includes acetylcholiestersae. The interaction of a biomarker so derived with a optical sensor comprising a receptor bound to a biopolymer results in an optical readout that reports the presence of the biomarker. In one aspect of the invention the receptor that is bound to a biopolymer, such as a poly-di-acetylene polymer, is a antibody that selectively recognizes the biomarker.
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Inventors:
Thompson, Charles, M.
Naji, John, Oh.
Naji, John, Oh.
Application Number:
JP2010534008A
Publication Date:
April 14, 2011
Filing Date:
May 15, 2008
Export Citation:
Assignee:
Atelis Technologies, LRC
Thompson, Charles, M.
Naji, John, Oh.
Thompson, Charles, M.
Naji, John, Oh.
International Classes:
G01N33/53; C07K7/06; C07K7/08; C07K16/00; C12N15/02; G01N37/00; C12P21/08
Domestic Patent References:
| JP2003528309A | 2003-09-24 | |||
| JP2007161717A | 2007-06-28 |
Other References:
JPN6012045494; Ｋａｔｈｌｅｅｎ Ｍ． Ｇｅｏｒｇｅ: 'Ｄｉｆｆｅｒｅｎｔｉａｔｉｏｎ ｂｅｔｗｅｅｎ Ａｃｅｔｙｌｃｈｏｌｉｎｅｓｔｅｒａｓｅ ａｎｄ ｔｈｅ Ｏｒｇａｎｏｐｈｏｓｐｈａｔｅ-ｉｎｈｉｂｉｔｅｄ Ｆｏｒｍ Ｕｓｉｎｇ Ａｎｔｉｂｏｄｉｅｓ' Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｂｉｏｌｏｇｉｃａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．２７８／Ｎ０．４６, 20031114, ４５５１２-４５５１８
Attorney, Agent or Firm:
Yoshiyuki Inaba
Toshifumi Onuki
Toshifumi Onuki