Title:
鉱質コルチコイドレセプターの活性化のバイオマーカー
Document Type and Number:
Japanese Patent JP2012506245
Kind Code:
A
Abstract:
The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
Inventors:
Jessel, Frederick
Farman, Nicolette
Santo-Marie, Yani
La Toche, Celine
Stealman, Maruya
Farman, Nicolette
Santo-Marie, Yani
La Toche, Celine
Stealman, Maruya
Application Number:
JP2011532624A
Publication Date:
March 15, 2012
Filing Date:
October 21, 2009
Export Citation:
Assignee:
Institut National De La Sante & De La Recherche Medical
International Classes:
C12Q1/68; A61K45/00; A61P3/00; A61P3/04; A61P3/10; A61P9/10; A61P43/00; C12N9/99; G01N33/53; C12N15/09
Domestic Patent References:
| JP2007516693A | 2007-06-28 | |||
| JP2004518611A | 2004-06-24 |
Foreign References:
| WO2008060607A2 | 2008-05-22 | |||
| WO2008030370A1 | 2008-03-13 |
Other References:
JPN5012002755; ＯＷＥＮ Ｈ Ｃ ｅｔ ａｌ: ＡＭＥＲＩＣＡＮ ＪＯＵＲＮＡＬ ＯＦ ＰＨＹＳＩＯＬＯＧＹ， ＥＮＤＯＣＲＩＮＯＬＯＧＹ ＡＮＤ ＭＥＴＡＢＯＬＩＳＭ Ｖｏｌ． ２９４, 20080401, ｐ． Ｅ１０２３-Ｅ１０３４
JPN5012002757; ＰＡＬＡＣＩＯＳ Ｓ ｅｔ ａｌ: ＭＡＴＵＲＩＴＡＳ Ｖｏｌ． ５５, 2006, ｐ． ２９７-３０７, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲＳ ＩＲＥＬＡＮＤ ＬＴＤ
JPN5012002758; ＰＡＲＴＨＡＳＡＲＡＴＨＹ ＨＡＲＩ Ｋ ｅｔ ａｌ: ＢＭＣ ＣＡＲＤＩＯＶＡＳＣＵＬＡＲ ＤＩＳＯＲＤＥＲＳ Ｖｏｌ． ７, 20070509, ＢＩＯＭＥＤ ＣＥＮＴＲＡＬ
JPN5012002759; ＬＩＭ Ｐ Ｏ ｅｔ ａｌ: ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＰＨＡＲＭＡＣＯＬＯＧＹ Ｖｏｌ． ４８, 199911, ｐ． ７５６-７６０
JPN5012002760; ＢＥＴＴＥＮＣＯＵＲＴ ＰＡＵＬＯ ｅｔ ａｌ: ＣＩＲＣＵＬＡＴＩＯＮ Ｖｏｌ． １１０, 20041012, ｐ． ２１６８-２１７４
JPN5012002761; ＴＳＵＴＡＭＯＴＯ Ｔ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＯＬＬＥＧＥ ＯＦ ＣＡＲＤＩＯＬＯＧＹ Ｖｏｌ． ３７， Ｎｏ． ５, 200104, ｐ． １２２８-１２３３
JPN5012002762; ＢＯＣＣＡＮＥＬＬＩ ＡＬＥＳＳＡＮＤＲＯ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＣＡＲＤＩＯＶＡＳＣＵＬＡＲ ＭＥＤＩＣＩＮＥ Ｖｏｌ． ８， Ｎｏ． ９, 2007, ｐ． ６８３-６９１
JPN5012002765; ＢＲＡＤＳＴＲＥＥＴ ｅｔ ａｌ: ＭＥＤＩＣＡＬ ＨＹＰＯＴＨＥＳＥＳ Ｖｏｌ． ６８, 2007, ｐ． ９７９-９８７, ＥＤＥＮ ＰＲＥＳＳ
JPN5012002766; ＢＯＬＴＥＮ ＣＨＡＲＬＥＳ Ｗ ｅｔ ａｌ: ＥＮＤＯＣＲＩＮＯＬＯＧＹ Ｖｏｌ． １４７， Ｎｏ． ７, 200607, ｐ． ３１８１-３１８２
JPN5012002768; ＣＩＣＨＹ ＪＯＡＮＮＡ ｅｔ ａｌ: ＦＥＢＳ ＬＥＴＴＥＲＳ Ｖｏｌ． ３５９, 1995, ｐ． ２６２-２６６
JPN5012002767; ＮＡＧＡＲＥＤＡ Ｔ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＰＡＴＨＯＬＯＧＹ Ｖｏｌ． １６５, 1991, ｐ． ３１９-３２４
JPN6014010700; 槙田: 医学のあゆみ Ｖｏｌ． ２２１， Ｎｏ． ９, 20070602, ｐ． ８０９-８１１
JPN6014010701; 長瀬 他: 実験医学 Ｖｏｌ． ２５， Ｎｏ． １５, 2007, ｐ． ２２３-２２７
JPN5012002754; ＨＡＮＳＥＮ ＰＥＴＥＲ ＲＩＩＳ ｅｔ ａｌ: ＩＭＭＵＮＯＬＯＧＹ ＬＥＴＴＥＲＳ Ｖｏｌ． ９１, 2004, ｐ． ８７-９１
JPN5012002756; ＰＡＲＴＨＡＳＡＲＡＴＨＹ Ｈ Ｋ ｅｔ ａｌ: ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＤＩＡＢＥＴＥＳ ＡＮＤ ＶＡＳＣＵＬＡＲ ＤＩＳＥＡＳＥ Ｖｏｌ． ８， Ｎｏ． ５, 200809, ｐ． ２１５-２１９
JPN5012002753; ＷＡＮＧ ＹＵ ｅｔ ａｌ: ＣＬＩＮＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ． ５３， Ｎｏ． １, 2007, ｐ． ３４-４１, ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＬＩＮＩＣＡＬ ＣＨＥＭＩＳＴＲＹ
JPN5012002764; ＨＡＫ Ａ ＥＬＩＳＡＢＥＴＨ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＥＮＤＯＣＲＩＮＯＬＯＧＹ ＡＮＤ ＭＥＴＡＢＯＬＩＳＭ Ｖｏｌ． ８６， Ｎｏ． ９, 200109, ｐ． ４３９８-４４０５
JPN5012002763; ＤＩＫ ＭＩＲＡＮＤＡ Ｇ ｅｔ ａｌ: ＤＩＡＢＥＴＥＳ ＣＡＲＥ Ｖｏｌ． ３０， Ｎｏ． １０, 200710, ｐ． ２６５５-２６６０
JPN6014010703; Ｓｔｒａｔｉｌ ｅｔ ａｌ: Ｇｅｎｅ Ｖｏｌ． ２９２, 2002, ｐ． １１３-１１９
JPN5012002757; ＰＡＬＡＣＩＯＳ Ｓ ｅｔ ａｌ: ＭＡＴＵＲＩＴＡＳ Ｖｏｌ． ５５, 2006, ｐ． ２９７-３０７, ＥＬＳＥＶＩＥＲ ＳＣＩＥＮＣＥ ＰＵＢＬＩＳＨＥＲＳ ＩＲＥＬＡＮＤ ＬＴＤ
JPN5012002758; ＰＡＲＴＨＡＳＡＲＡＴＨＹ ＨＡＲＩ Ｋ ｅｔ ａｌ: ＢＭＣ ＣＡＲＤＩＯＶＡＳＣＵＬＡＲ ＤＩＳＯＲＤＥＲＳ Ｖｏｌ． ７, 20070509, ＢＩＯＭＥＤ ＣＥＮＴＲＡＬ
JPN5012002759; ＬＩＭ Ｐ Ｏ ｅｔ ａｌ: ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＰＨＡＲＭＡＣＯＬＯＧＹ Ｖｏｌ． ４８, 199911, ｐ． ７５６-７６０
JPN5012002760; ＢＥＴＴＥＮＣＯＵＲＴ ＰＡＵＬＯ ｅｔ ａｌ: ＣＩＲＣＵＬＡＴＩＯＮ Ｖｏｌ． １１０, 20041012, ｐ． ２１６８-２１７４
JPN5012002761; ＴＳＵＴＡＭＯＴＯ Ｔ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＴＨＥ ＡＭＥＲＩＣＡＮ ＣＯＬＬＥＧＥ ＯＦ ＣＡＲＤＩＯＬＯＧＹ Ｖｏｌ． ３７， Ｎｏ． ５, 200104, ｐ． １２２８-１２３３
JPN5012002762; ＢＯＣＣＡＮＥＬＬＩ ＡＬＥＳＳＡＮＤＲＯ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＣＡＲＤＩＯＶＡＳＣＵＬＡＲ ＭＥＤＩＣＩＮＥ Ｖｏｌ． ８， Ｎｏ． ９, 2007, ｐ． ６８３-６９１
JPN5012002765; ＢＲＡＤＳＴＲＥＥＴ ｅｔ ａｌ: ＭＥＤＩＣＡＬ ＨＹＰＯＴＨＥＳＥＳ Ｖｏｌ． ６８, 2007, ｐ． ９７９-９８７, ＥＤＥＮ ＰＲＥＳＳ
JPN5012002766; ＢＯＬＴＥＮ ＣＨＡＲＬＥＳ Ｗ ｅｔ ａｌ: ＥＮＤＯＣＲＩＮＯＬＯＧＹ Ｖｏｌ． １４７， Ｎｏ． ７, 200607, ｐ． ３１８１-３１８２
JPN5012002768; ＣＩＣＨＹ ＪＯＡＮＮＡ ｅｔ ａｌ: ＦＥＢＳ ＬＥＴＴＥＲＳ Ｖｏｌ． ３５９, 1995, ｐ． ２６２-２６６
JPN5012002767; ＮＡＧＡＲＥＤＡ Ｔ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＰＡＴＨＯＬＯＧＹ Ｖｏｌ． １６５, 1991, ｐ． ３１９-３２４
JPN6014010700; 槙田: 医学のあゆみ Ｖｏｌ． ２２１， Ｎｏ． ９, 20070602, ｐ． ８０９-８１１
JPN6014010701; 長瀬 他: 実験医学 Ｖｏｌ． ２５， Ｎｏ． １５, 2007, ｐ． ２２３-２２７
JPN5012002754; ＨＡＮＳＥＮ ＰＥＴＥＲ ＲＩＩＳ ｅｔ ａｌ: ＩＭＭＵＮＯＬＯＧＹ ＬＥＴＴＥＲＳ Ｖｏｌ． ９１, 2004, ｐ． ８７-９１
JPN5012002756; ＰＡＲＴＨＡＳＡＲＡＴＨＹ Ｈ Ｋ ｅｔ ａｌ: ＢＲＩＴＩＳＨ ＪＯＵＲＮＡＬ ＯＦ ＤＩＡＢＥＴＥＳ ＡＮＤ ＶＡＳＣＵＬＡＲ ＤＩＳＥＡＳＥ Ｖｏｌ． ８， Ｎｏ． ５, 200809, ｐ． ２１５-２１９
JPN5012002753; ＷＡＮＧ ＹＵ ｅｔ ａｌ: ＣＬＩＮＩＣＡＬ ＣＨＥＭＩＳＴＲＹ Ｖｏｌ． ５３， Ｎｏ． １, 2007, ｐ． ３４-４１, ＡＭＥＲＩＣＡＮ ＡＳＳＯＣＩＡＴＩＯＮ ＦＯＲ ＣＬＩＮＩＣＡＬ ＣＨＥＭＩＳＴＲＹ
JPN5012002764; ＨＡＫ Ａ ＥＬＩＳＡＢＥＴＨ ｅｔ ａｌ: ＪＯＵＲＮＡＬ ＯＦ ＣＬＩＮＩＣＡＬ ＥＮＤＯＣＲＩＮＯＬＯＧＹ ＡＮＤ ＭＥＴＡＢＯＬＩＳＭ Ｖｏｌ． ８６， Ｎｏ． ９, 200109, ｐ． ４３９８-４４０５
JPN5012002763; ＤＩＫ ＭＩＲＡＮＤＡ Ｇ ｅｔ ａｌ: ＤＩＡＢＥＴＥＳ ＣＡＲＥ Ｖｏｌ． ３０， Ｎｏ． １０, 200710, ｐ． ２６５５-２６６０
JPN6014010703; Ｓｔｒａｔｉｌ ｅｔ ａｌ: Ｇｅｎｅ Ｖｏｌ． ２９２, 2002, ｐ． １１３-１１９
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito