Title:
ビフェニル誘導体及びC型肝炎の治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP2009538890
Kind Code:
A
Abstract:
Compounds of formula (I) are found to be active against HCV. wherein: R1 is a moiety -A1-L1-A1', -A1-L1-A1'-A1" or -A1-L1-A1'-Y1-A1"; A and B are the same or different and each represent a direct bond or a -CO- NR'-, -NR'-CO-, -NR'-CO-NR"-, -NR'-S(O)2-, -S(O)2-NR'- or -NR'- moiety, wherein R' and R" are the same or different and each represent hydrogen or C1-C4 alkyl; R2 and R3 are the same or different and each represent C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 haloalkyl, C1-C4 haloalkoxy, halogen, hydroxy, thio, -NR'R", -SO2-R'", -NR'-COR'" or -CO2R'", wherein R' and R" are the same or different and represent hydrogen or C1-C4 alkyl and R'" represents C1-C4 alkyl; n and m are the same or different and each represent 0, 1 or 2; R4 is a C1-C6 alkyl or C1-C6 haloalkyl group or a moiety -A4, -A4-A4', -L4-A4, -A4-L4-A4', -A4-Het4-L4-Het4'-L4' or -L4-Het4-L4', - each A1, A4, A1', A1" and A4' are the same or different and represent a phenyl, 5- to 10- membered heteroaryl, 5- to 10- membered heterocyclyl or C3-C6carbocyclyl moiety; each L1 and L4 is the same or different and represents a C1-C4alkylene or a C1-C4 hydroxyalkylene group; - Y1 represents -CO-NR'-, -CO-( C1-C4 alkylene)-, -CO-( C1-C4 alkylene)-NR'-, -NR'-CO-, -CO-, -O-CO- or -CO-O-, wherein R' is hydrogen or C1-C4 alkyl; L4' represents hydrogen or a C1-C4 alkyl group; Het4 and Het4' are the same or different and represent -O-, -S- or -NR'-, wherein R' is hydrogen or a C1-C4 alkyl group; the phenyl, heteroaryl, heterocyclyl and carbocyclyl moieties in R1 and R4 being unsubstituted or substituted by (a) a single unsubstituted substituent selected from -CO2R', -SO2NR"R', -S(O)2-R', -CONR"R", -COR'", -CO-CO-OR''', -CO-( C1-C4 alkylene)-OR", -CO-( C1-C4 alkylene)-NR"R", -CO-( C1-C4 alkylene)-NR"-CO-R''', -CO- (C1-C4 alkylene)-CO-NR"R", -CO-( C1-C4 alkylene)-SO2-R'", -CO-( C1-C4 alkylene)-O- (C1-C4 alkylene)-OR", -CO-( C1-C4 alkylene)-O-( C1-C4 alkylene)-NR"R", -CO-( C1-C4 alkylene)-NR"-( C1-C4 alkylene)-OR", -CO-( C1-C4 alkylene)-NR"-( C1-C4 alkylene)- NR"R", -SO2-( C1-C4 alkylene)-OR", -NR"-SO2-R'", -( C1-C4 alkylene)-CO-( C1-C4 alkylene)-CO
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Inventors:
Ramley, james
James Earin, Salter
Carter, Malcolm Clive
Matthews, Neil
Pilkington, Christopher John
Alexander James Floyd, Thomas
Fraser, Ian
James Earin, Salter
Carter, Malcolm Clive
Matthews, Neil
Pilkington, Christopher John
Alexander James Floyd, Thomas
Fraser, Ian
Application Number:
JP2009512654A
Publication Date:
November 12, 2009
Filing Date:
March 21, 2007
Export Citation:
Assignee:
Arrow Therapeutics Limited
International Classes:
C07D207/14; A61K31/40; A61K31/495; A61K31/496; A61K31/5375; A61K31/54; A61K31/7052; A61K38/21; A61P1/16; A61P31/12; C07D207/16; C07D211/58; C07D211/88; C07D213/75; C07D233/32; C07D249/08; C07D295/04; C07D295/12; C07D295/18; C07D295/22
Attorney, Agent or Firm:
Shinjiro Ono
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Naoshi Nakata
Kazuo Shamoto
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Naoshi Nakata