Title:
11-β-ヒドロキシステロイドデヒドロゲナーゼ1阻害剤としてのビフェニルアミドラクタム誘導体
Document Type and Number:
Japanese Patent JP5265521
Kind Code:
B2
Abstract:
The present invention discloses novel compounds of Formula I: possessing 11 β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, cognitive disorders, and other conditions associated with 11 β-HSD type 1 activity.
Inventors:
Thomas Daniel Acre
Chaogen Chen
Ronald Jay Hinklin
Gary Alan Height
Alexei Pavlovich Krasutsky
Renhua Li
Jefferson Ray McCowan
Ashraf Said
Nancy June Snyder
James Lee Toss
Owen Brendan Wallace
Leonard Larry Winaroski Jr.
Yampin Shu
Jeremy Schulenburg York
Chaogen Chen
Ronald Jay Hinklin
Gary Alan Height
Alexei Pavlovich Krasutsky
Renhua Li
Jefferson Ray McCowan
Ashraf Said
Nancy June Snyder
James Lee Toss
Owen Brendan Wallace
Leonard Larry Winaroski Jr.
Yampin Shu
Jeremy Schulenburg York
Application Number:
JP2009506764A
Publication Date:
August 14, 2013
Filing Date:
April 19, 2007
Export Citation:
Assignee:
Eli Lilly and Company
International Classes:
C07D207/26; A61K31/4015; A61K31/4025; A61K31/41; A61K31/437; A61K31/4439; A61K31/454; A61K31/496; A61K31/4985; A61K31/4995; A61K31/5377; A61K31/5383; A61K31/5386; A61K31/541; A61K31/553; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P9/12; A61P43/00; C07D401/10; C07D401/12; C07D403/10; C07D403/12; C07D413/10; C07D471/04; C07D487/04; C07D487/08; C07D491/08; C07D498/04
Foreign References:
| WO2005108361A1 | ||||
| WO2006104280A1 | ||||
| WO2006049952A1 |
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Masahiro Nitta
Samejima Mutsumi
Masahiro Nitta