Title:
BIS-TETRAZOLEMETHYL SUBSTITUTED BETA-LACTAM ANTIBIOTIC
Document Type and Number:
Japanese Patent JPS5781489
Kind Code:
A
Abstract:
Broad spectrum beta -lactam antibiotics represented by the formula wherein R is the residue of a carboxylic acid, R2 is H or OCH3, and R4 is hydrogen or C1-C3 alkyl; are obtained by reacting a 7-acylamino-3-halomethyl-1-oxa- beta -lactam ester with the desired 1- or 2-tetrazolemethyl substituted 1H or 2H tetrazole-5-thiol. Alternatively, a 7-amino-3-halo-methyl-1-oxa- beta -lactam ester is first reacted with the bis-tetrazole thiol and then the product is N-acylated with the desired carboxylic acid.
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Inventors:
AREN ESU KAATONAA
Application Number:
JP14770381A
Publication Date:
May 21, 1982
Filing Date:
September 16, 1981
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/535; A61P31/04; C07D257/04; C07D505/00; (IPC1-7): A61K31/535; C07D257/04; C07D498/04