Title:
ＤＬＬ３及びＣＤ３に結合する二重特異性抗体構築物
Document Type and Number:
Japanese Patent JP7166368
Kind Code:
B2
Abstract:
The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human DLL3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
Inventors:
Raum Tobias
Kufer Peter
Pentozialech Jochen
Blumel Claudia
Darhof Christoph
Hoffman Patrick
Lutterbuese Ralf
Narwald Elizabeth
Kufer Peter
Pentozialech Jochen
Blumel Claudia
Darhof Christoph
Hoffman Patrick
Lutterbuese Ralf
Narwald Elizabeth
Application Number:
JP2021006315A
Publication Date:
November 07, 2022
Filing Date:
January 19, 2021
Export Citation:
Assignee:
AMGEN Research(Munich)GmbH
International Classes:
C07K16/46; A61K39/395; A61P35/00
Foreign References:
| WO2013126746A2 | ||||
| WO2014125273A1 |
Other References:
BIOSCIENCE TRENDS,2009年08月,VOL:3, NR:4,PAGE(S):131 - 138
CANCER LETTERS,2013年02月10日,VOL:335, NR:1,PAGE(S):153 - 159,http://dx.doi.org/10.1016/j.canlet.2013.02.009
CANCER LETTERS,2013年02月10日,VOL:335, NR:1,PAGE(S):153 - 159,http://dx.doi.org/10.1016/j.canlet.2013.02.009
Attorney, Agent or Firm:
Shimizu Hatsushi
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Kazuya Kawamoto