Title:
二重特異性抗体
Document Type and Number:
Japanese Patent JP7230819
Kind Code:
B2
Abstract:
The present invention addresses the problem of providing a novel medical agent for prevention of auto-immune diseases, inhibition of symptom progression thereof, inhibition of recurrence thereof, or treatment thereof. As a result of conducting extensive studies, the inventors of the present invention have focused attention on PD-1/CD19 bispecific antibody as a substance with the potentiality of solving the problem, and have achieved the present invention. The PD-1/CD19 bispecific antibody according to the present invention exhibits growth-inhibitory action and immunoglobulin production inhibitory action against activated B cells, and also has inhibitory action against production of cytokine from memory T cells.
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Inventors:
Shibayama Shiro
Tomoya Tezuka
Tomoya Tezuka
Application Number:
JP2019547025A
Publication Date:
March 01, 2023
Filing Date:
October 05, 2018
Export Citation:
Assignee:
Ono Pharmaceutical Co., Ltd.
International Classes:
A61K39/395; A61P37/06; A61P43/00; C07K16/28; C07K16/46
Foreign References:
| CN106939050A | ||||
| WO2013022091A1 | ||||
| WO2003011911A1 | ||||
| WO2004072286A1 |
Other References:
SPIESS C.,ZHAI Q. and CARTER P.J.,Alternative molecular formats and therapeutic applications for bispecific antibodies.,Molecular Immunology,2015年01月27日,67,pp.95-106
BRINKMANN U. and KONTERMANN R.E.,The making of bispecific antibodies.,MABS,2017年01月10日,9(2),pp.182-212
BRINKMANN U. and KONTERMANN R.E.,The making of bispecific antibodies.,MABS,2017年01月10日,9(2),pp.182-212
Attorney, Agent or Firm:
Saegusa International Patent Office