Title:
BMP-ALK3 ANTAGONISTS AND USES THEREOF FOR PROMOTING BONE GROWTH
Document Type and Number:
Japanese Patent JP2015157856
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide BMP-ALK3 antagonists and uses thereof for promoting bone growth.SOLUTION: In certain aspects, the invention provides a composition and method for promoting bone growth and increasing bone density and strength. In certain embodiments, the invention provides ALK3 polypeptides including ALK3-Fc fusion proteins. The invention demonstrates that a soluble form ALK3 acts as an inhibitor of BMP-ALK3 signaling, and promotes increase in bone density, bone growth and bone strength in vivo. Although it is not desirable to be limited to a specific mechanism, it appears that the soluble form ALK3 achieves this action by inhibiting BMP2 and/or BMP4 and perhaps other ligands that signal through ALK3.
Inventors:
JASBIR SEEHRA
Application Number:
JP2015107063A
Publication Date:
September 03, 2015
Filing Date:
May 27, 2015
Export Citation:
Assignee:
ACCELERON PHARMA INC
International Classes:
C07K14/47; A61K38/00; A61K39/395; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C12N5/10; C12N15/09; C12N15/113; C12P21/02
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita