Title:
脳疾患治療剤
Document Type and Number:
Japanese Patent JP4255138
Kind Code:
B2
Abstract:
The present invention discloses the use, in the manufacture of a preventive and therapeutic drug of a brain disease, of a compound represented by formula (1): CH2=CH-CH2-S(O)n-R Äwherein R represents a hydrogen atom, an alkyl group, an alkenyl group, a substituted alkyl group, a substituted alkenyl group, an alkylthio group, an alkenylthio group, a phenyl group, a substituted phenyl group, a heterocyclic group, or a group derived from an amino acid or an oligopeptide by deletion of one hydrogen atom, and which group may have a protective group; and n is 0, 1, or 2Ü, a glycoside thereof, or a salt of the compound or the glycoside. The drug of the present invention for ameliorating brain diseases, inhibiting reduction of brain neurons and promoting branching of neurites, is useful for the prevention and treatment of brain diseases such as dementia in association with degeneration and sloughing of brain neurons.
Inventors:
Toru Moriguchi
Matsuura Hiromichi
Hiroshi Saito
Matsuura Hiromichi
Hiroshi Saito
Application Number:
JP12945896A
Publication Date:
April 15, 2009
Filing Date:
May 24, 1996
Export Citation:
Assignee:
Yukunaga Pharmaceutical Co., Ltd.
International Classes:
A61K31/095; A61K31/10; C07D263/58; A61K31/105; A61K31/185; A61K31/19; A61K31/192; A61K31/194; A61K31/195; A61K31/198; A61K31/42; A61K31/423; A61K31/60; A61K31/70; A61K31/7004; A61K38/00; A61K38/05; A61P25/28; C07C317/08; C07C317/44; C07C317/48; C07C321/08; C07C321/18; C07C321/24; C07C323/54; C07C323/58; C07C323/59; C07C323/62; C07H7/02; C07K5/062; C07K5/093; C07K14/415
Foreign References:
| WO1994017803A1 |
Other References:
Cancer Letters,1992年,Vol.63, No.3,pp.211-219
Ann. Pharm. Fr.,1978年,Vol.36, No.11-12,pp.581-586
Ann. New York Acad. Sci.,1982年,Vol.378,pp.316-326
J. Med. Chem.,1996年 1月,Vol.39, No.2,pp.398-406
Ann. Pharm. Fr.,1978年,Vol.36, No.11-12,pp.581-586
Ann. New York Acad. Sci.,1982年,Vol.378,pp.316-326
J. Med. Chem.,1996年 1月,Vol.39, No.2,pp.398-406
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Hiromi Matoba