Title:
リポ多糖を用いた脳機能改善剤、食品及び医薬品
Document Type and Number:
Japanese Patent JP6998133
Kind Code:
B2
Abstract:
A readily-available brain function-improving agent or food composition having an Aβ intracerebral deposition suppressing effect or a learning function-improving effect is provided based on finding, as a result of orally administering Pantoea LPS to Alzheimer's disease model mice and studying the effects, that oral administration of Pantoea LPS significantly decreased intracerebral Aβ peptide accumulation and improved learning function.
Inventors:
Gen Genichiro
Hiroyuki Inagawa
Chie Kawachi
Yutaro Kobayashi
Hiroyuki Inagawa
Chie Kawachi
Yutaro Kobayashi
Application Number:
JP2017105133A
Publication Date:
January 18, 2022
Filing Date:
May 28, 2017
Export Citation:
Assignee:
Innate immune control technology research association
Biomedical Research Group Ltd.
Natural immunity applied technology research institute
National University Corporation Kagawa University
Biomedical Research Group Ltd.
Natural immunity applied technology research institute
National University Corporation Kagawa University
International Classes:
A61K31/739; A23L33/10; A61K35/74; A61K35/741; A61P25/28
Other References:
池田幸矢 ほか,マクロファージ細胞株RAW264.7におけるPantoea agglomerans由来LPSの貪食能活性化に関する検討,バイオ治療法研究会学術集会プログラム・抄録集,2016年,第20回,p.42,特に「背景・目的」欄
INAGAWA, Hiroyuki et al.,Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea a,in vivo,2016年,Vol.30,pp.205-211,ISSN:0258-851X, 特に第210頁左欄第27行~第36行
KOBAYASHI, Y. et al.,Effect of Lipopolysaccharide Derived from Pantoea agglomerans on the Phagocytic Activity of Amyloid,Anticancer Res.,2016年,Vol.36(7),pp.3693-3698,ISSN:0250-7005, 特に「アブストラクト」、第3693頁右欄第1行~第7行、第19行、第3693頁右欄第
INAGAWA, Hiroyuki et al.,Primed Activation of Macrophages by Oral Administration of Lipopolysaccharide Derived from Pantoea a,in vivo,2016年,Vol.30,pp.205-211,ISSN:0258-851X, 特に第210頁左欄第27行~第36行
KOBAYASHI, Y. et al.,Effect of Lipopolysaccharide Derived from Pantoea agglomerans on the Phagocytic Activity of Amyloid,Anticancer Res.,2016年,Vol.36(7),pp.3693-3698,ISSN:0250-7005, 特に「アブストラクト」、第3693頁右欄第1行~第7行、第19行、第3693頁右欄第
Attorney, Agent or Firm:
Kazuo Nakamura