PURPOSE: To produce a branched alkylamino deriv. of thiazole used for the treatment of diseases which require the controlling of the effect of corticotropin releasing hormone.
CONSTITUTION: This compd. (e.g. 4-(2,4-dichlorophenyl)-5-methyl-2-(N-(cyclo(4- pyridyl)methyl)-N-propylamino)thiazole is expressed by formula I. In the formula I, R1 is formula II, formula III (X, Y, Z are H, halogen, alkoxy, alkyl, OH, CN or the like); R2 is H, halogen, alkyl, hydroxymethyl or formyl; R3 is alkyl, cycloalkyl, alkenyl, cycloalkylalkyl or phenyl; R4 is H, alkyl, cycloalkyl or cycloalkylalkyl; R5 is alkyl, cycloalkyl which may be substituted with alkyl, cycloalkylalkyl, alkenyl or formula IV (p is 0 to 3); R6 is phenyl, pyridyl, imidazolyl, pyrrolyl, thienyl or furyl, which may be substituted; m, n are 0 or 1.
| JP3179286 | N-HYDROXYUREA-BASED ANTI-INFLAMMATORY AGENT |
| WO/2010/044405 | FUSED-RING DERIVATIVE AND MEDICAL APPLICATION OF SAME |
| WO/2020/102575 | HETEROCYCLIC AMINOTHIAZOLES AND USES THEREOF |
KUROODEI GOTEIE
DANIERU GIYURII
PIEERU ROJIE
JIERAARU BUARETSUTO
KAMIIYU JIYORUJIYU UERUMIYUTO
