Title:
BREAST CANCER THERAPEUTIC MEDICINE CONTAINING PYRIDAZINE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JP3229738
Kind Code:
B2
Abstract:
PURPOSE: To provide a low toxic breast cancer therapeutic medicine containing a pyridazine derivative as an active ingredient and having an aromatase- inhibiting activity.
CONSTITUTION: A breast cancer-treating agent contains a 3-(1H-imidazol-1- yl)pyridazine derivative of the formula (R1 is H, lower alkyl; R2 is benzyl, naphthylmethyl) or its salt as an active ingredient, can be prepared in the form of an oral administration agent or an injection agent, and is administered at a dose of approximately 0.01-200mg/kg once to several times a day for an adult. Since little in affections against other steroid-metabolizing enzyme systems and high in safety, the compound of the formula is useful for the therapy of hormone-dependent breast cancers as an aromatase-inhibiting agent having selectivity.
Inventors:
Bando Kosuke
Yasuhiro Ishizuka
Hiroshi Shimamura
Koji Terashima
Yasuhiro Ishizuka
Hiroshi Shimamura
Koji Terashima
Application Number:
JP30745293A
Publication Date:
November 19, 2001
Filing Date:
November 11, 1993
Export Citation:
Assignee:
Ajinomoto Pharma Co., Ltd.
International Classes:
C07D403/04; A61K31/50; A61K31/501; A61P35/00; (IPC1-7): A61K31/501; A61P35/00; C07D403/04
Domestic Patent References:
| JP1139578A |
Attorney, Agent or Firm:
Chika Takagi (1 person outside)