Title:
C-19 ornamentation triterpenoid which has HIV mature prevention activity
Document Type and Number:
Japanese Patent JP6186010
Kind Code:
B2
Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-19 modified triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I and II: These compounds are useful for the treatment of HIV and AIDS.
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Inventors:
Jacob Swidoski
Brian Lee Bennables
Chen Liu
Herring
Nicholas A. Meanwell
Alicia Regueiro-Len
Brian Lee Bennables
Chen Liu
Herring
Nicholas A. Meanwell
Alicia Regueiro-Len
Application Number:
JP2015556998A
Publication Date:
August 23, 2017
Filing Date:
February 04, 2014
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07J63/00; A61K31/19; A61K31/194; A61K31/5375; A61K31/54; A61K45/00; A61P31/12; A61P31/18; A61P43/00
Domestic Patent References:
| JP7501068A |
Foreign References:
| WO2011153315A1 | ||||
| WO2012106190A1 | ||||
| WO2012106188A1 |
Other References:
EVERS,M. et al,Betulinic Acid Derivatives: A New Class of Human Immunodeficiency Virus Type 1 Specific Inhibitors with a New Mode of Action,Journal of Medicinal Chemistry,1996年,Vol.39, No.5,p.1056-68
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Kamahira Futami
Kure Hidenori
Nagatoshi Shinagawa
Kamahira Futami
Kure Hidenori