Title:
C-23-MODIFIED DERIVATIVE OF OMT
Document Type and Number:
Japanese Patent JPS5931795
Kind Code:
A
Abstract:
C-23-Modified derivatives of 5-O-mycaminosyl-tylonolide (OMT) of the formula: 1 wherein R is chloro, fluoro, -S-R4, azido, -NHR5, pyridinium, or -OSO2CF3; R1 is hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl, phenylpropionyl, phenoxyacetyl or phenylthioacetyl; R2 and R3 are hydrogen, optionally substituted C1-C5-alkanoyl or optionally substituted benzoyl, phenylacetyl or phenylpropionyl; R4 is hydrogen, optionally substituted C1-C6-alkyl, cyclohexyl, C1-C5 alkanoyl, optionally substituted phenyl or benzyl, or an optionally substituted heteroaryl group selected from imidazolyl, pyrazolyl, pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, thiadiazolyl, thienyl and furanyl; and R5 is hydrogen or an acyl group selected from optionally substituted C1-C5-alkanoyl, optionally substituted benzoyl, phenylacetyl, or phenylpropionyl or optionally substituted phenylglycyl or phenylalanyl; and of the formula: 2 wherein: R6 and R7 together form a CH2= group or R6 is R8O- and R7 is methyl; R8 is C1-C4-alkyl, benzyl or phenethyl; and R1, R2 and R3 are as defined in formula 1; and salts thereof are useful antibiotics or intermediates to antibiotics.
Inventors:
HAABAATO ANDORIYUU KAASUTO
JIYON ERUDON TOSU
JIYON ERUDON TOSU
Application Number:
JP13179283A
Publication Date:
February 20, 1984
Filing Date:
July 18, 1983
Export Citation:
Assignee:
LILLY CO ELI
International Classes:
A61K31/70; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): A61K31/71; C07H17/08
Attorney, Agent or Firm:
Aoyama