Title:
ＨＩＶ成熟阻害剤としての修飾Ｃ−３ベツリン酸誘導体のＣ−２８アミド
Document Type and Number:
Japanese Patent JP5755731
Kind Code:
B2
Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors. These compounds are useful for the treatment of HIV and AIDS.
Inventors:
Alicia Regueiro-Len
Chen Liu
Jacob Swidoski
Nicholas A. Meanwell
Shin-Yuen Sitt
Chen Jie
Yang Chen
Nai Singh
Chen Liu
Jacob Swidoski
Nicholas A. Meanwell
Shin-Yuen Sitt
Chen Jie
Yang Chen
Nai Singh
Application Number:
JP2013513340A
Publication Date:
July 29, 2015
Filing Date:
June 02, 2011
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07J63/00; A61K31/56; A61K31/58; A61K45/00; A61P31/12
Domestic Patent References:
| JP2008519857A | ||||
| JP2009527563A | ||||
| JP2002505337A | ||||
| JP2006504704A | ||||
| JP2011518192A | ||||
| JP2013519674A |
Foreign References:
| WO2008115281A1 | ||||
| WO2005112929A1 | ||||
| WO1996039033A1 | ||||
| WO2009020732A1 |
Other References:
Chemical & Pharmaceutical Bulletin,2000年,48(11),1681-1688
Journal of Medicinal Chemistry,1996年,39(5),1016-1017
Journal of Medicinal Chemistry,2006年,49(18),5462-5469
Journal of Medicinal Chemistry,1996年,39(5),1016-1017
Journal of Medicinal Chemistry,2006年,49(18),5462-5469
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto