Title:
C-3 Alkyl and a Alkenyl ornamentation betulic acid derivative
Document Type and Number:
Japanese Patent JP6186012
Kind Code:
B2
Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: a compound of Formula I a compound of Formula II a compound of Formula III and a compound of Formula IV The compounds are useful for the treatment of HIV and AIDS.
Inventors:
Jacob Swidoski
Yang Chen
Shin-Yuen Sitt
Nicholas A. Meanwell
Alicia Regueiro-Len
Chen Jie
Chen Liu
Richard A. Hearts
Re-Shoo
Yang Chen
Shin-Yuen Sitt
Nicholas A. Meanwell
Alicia Regueiro-Len
Chen Jie
Chen Liu
Richard A. Hearts
Re-Shoo
Application Number:
JP2015558996A
Publication Date:
August 23, 2017
Filing Date:
February 21, 2014
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07J63/00; A61K31/445; A61K31/54; A61K45/00; A61P31/18
Foreign References:
| WO2011153315A1 | ||||
| WO2012106190A1 | ||||
| WO2012106188A1 |
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Mizuhara Masahiro
Nagatoshi Shinagawa
Mizuhara Masahiro
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