Title:
C-3 cyclo Alke nil triterpenoid with HIV mature prevention activity
Document Type and Number:
Japanese Patent JP6155285
Kind Code:
B2
Abstract:
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, C-3 cycloalkenyl triterpenoids that possess unique antiviral activity are provided as HIV maturation inhibitors, as represented by compounds of Formulas I, II, III and IV: wherein X can be a C4-8 cycloalkyl, C4-8 cycloalkenyl, C4-9 spirocycloalkyl, C4-9 spirocycloalkenyl, C4-8 oxacycloalkyl, C4-8 dioxacycloalkyl, C6-8 oxacycloalkenyl, C6-8 dioxacycloalkenyl, C6-9 oxaspirocycloalkyl, or C6-9 oxaspirocycloalkenyl ring. These compounds are useful for the treatment of HIV and AIDS.
Inventors:
Jacob Swidoski
Nicholas A. Meanwell
Alicia Regueiro-Len
Shin-Yuen Sitt
Chen Jie
Yang Chen
Nicholas A. Meanwell
Alicia Regueiro-Len
Shin-Yuen Sitt
Chen Jie
Yang Chen
Application Number:
JP2014557739A
Publication Date:
June 28, 2017
Filing Date:
February 13, 2013
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C07J63/00; A61K31/565; A61P31/18; A61P37/04
Domestic Patent References:
| JP6001560B2 | ||||
| JP2013527242A | ||||
| JP2013527243A | ||||
| JP2015516422A | ||||
| JP2011511812A | ||||
| JP2011508748A | ||||
| JP2014526554A | ||||
| JP2014507422A | ||||
| JP2016507558A | ||||
| JP2014503595A |
Foreign References:
| WO2009020732A1 |
Other References:
Bioorganic & Medicinal Chemistry Letters,2001年,11,3115-3118
Attorney, Agent or Firm:
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Nishino Mitsuru
Nagatoshi Shinagawa
Yasushi Morimoto
Nishino Mitsuru