Title:
C3B ANTIBODY AND METHOD FOR PREVENTING AND TREATING COMPLEMENT-ASSOCIATED DISORDER
Document Type and Number:
Japanese Patent JP2016204382
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a therapeutic agent for preventing and treating complement-associated disorder by blocking C3b.SOLUTION: The present invention relates to a development of an antibody that specifically recognizes not natural C3 but a breakdown fragment of C3, which prevents the natural C3 from working as a "sink" of the antibody. More specifically, the present invention relates to a C3b-specific antibody and an antibody fragment, and use thereof in treating a complement-associated disease. The present invention also relates to a method for preventing and treating a complement-associated disorder which includes a process of administering an effective amount of C3b antagonist being a selective inhibitor of a second complement pathway to a subject that requires it.SELECTED DRAWING: None
Inventors:
MENNO VAN LOOKEREN CAMPAGNE
Application Number:
JP2016145975A
Publication Date:
December 08, 2016
Filing Date:
July 26, 2016
Export Citation:
Assignee:
GENENTECH INC
International Classes:
A61K45/00; A61K39/395; A61P3/10; A61P7/00; A61P7/08; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P19/02; A61P21/00; A61P27/02; A61P29/00; A61P37/06; A61P41/00; A61P43/00; C07K16/16
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita