C5AR ANTAGONISTS - CHEMOCENTRYX INC

Title:

C5AR ANTAGONISTS

Document Type and Number:

Japanese Patent JP2016130249

Kind Code:

A

Abstract:

PROBLEM TO BE SOLVED: To provide compounds that are modulators of the C5a receptor, and pharmaceutical compositions, comprising at least one of the compounds.SOLUTION: Compounds are provided that are modulators of the C5a receptor, where the compounds are substituted piperidines. There are also provided pharmaceutical compositions, comprising at least one of the compounds, for the treatment of diseases and disorders associated with the activation of C5a receptors.SELECTED DRAWING: Figure 1X

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Inventors:

FAN PINGCHEN
KEVIN LLOYD GREENMAN
MANMOHAN REDDY LELETI
LI YANDONG
JAY POWERS
TANAKA HIROKO
YANG JU
ZENG YIBIN

Application Number:

JP2016053725A

Publication Date:

July 21, 2016

Filing Date:

March 17, 2016

Export Citation:

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Assignee:

CHEMOCENTRYX INC

International Classes:

C07D211/60; A61K31/445; A61K31/451; A61K31/4525; A61K31/453; A61K31/454; A61K31/4545; A61K31/5377; A61P1/04; A61P1/18; A61P3/10; A61P3/12; A61P7/00; A61P7/02; A61P7/04; A61P9/00; A61P9/08; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/02; A61P17/04; A61P17/06; A61P19/02; A61P21/00; A61P21/04; A61P25/00; A61P25/28; A61P27/00; A61P29/00; A61P31/04; A61P35/00; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D401/04; C07D401/10; C07D401/12; C07D401/14; C07D405/12; C07D413/10; C07D413/12

Domestic Patent References:

JP5819730B2	2015-11-24
JP2008504275A	2008-02-14

Foreign References:

WO2007051062A2

2007-05-03

Other References:

BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 18, JPN6015015734, 2008, pages 5601 - 5604, ISSN: 0003588551
BRITISH JOURNAL OF PHARMACOLOGY, vol. 152, JPN6015015737, 2007, pages 429 - 448, ISSN: 0003588552

Attorney, Agent or Firm:

Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Ryotaro Takei
Yosuke Ito

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