CA6 antigen -- specific cytotoxic conjugate and directions for use for the same

Japanese Patent JP6144749

B2

Cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate are disclosed are all embodiments of the invention. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CA6 glycotope. The present invention is also directed to humanized or resurfaced versions of DS6, an anti-CA6 murine monoclonal antibody, and epitope-binding fragments thereof.

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Pain, Gillian
Chun, Philip
Danielle Tavares

JP2015237469A

June 07, 2017

December 04, 2015

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Immunogen Incorporated

A61K39/395; A61K31/337; A61K31/407; A61K31/537; A61K31/704; A61K45/00; A61K47/48; A61P35/00; C07H21/04; C07K14/47; C07K16/00; C07K16/30; C12N5/06; C12P21/06; A61K

JP6510671A

US6596503
WO2003057160A1
WO2003043583A1
WO2002098883A1
WO2002016401A1

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Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Hirose Shinobu

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