Title:
2つのベンズヒドリル部分を有するカルシウムチャンネルブロッカー
Document Type and Number:
Japanese Patent JP2006522741
Kind Code:
A
Abstract:
Compounds of the formula and their salts, wherein Cy represents cyclohexyl; Y is CH-CHPhi, CHPhi2, Phi or Cy, X is trivalent straight-chain alkylene (3-10C) or trivalent straight-chain 1-alkenylene (3-10C) optionally substituted by oxo at the C adjacent N when n is 0 and Y is Phi2CH; and is otherwise trivalent straight-chain alkylene (5-10C) or trivalent straight-chain 1-alkenylene (5-10C) optionally substituted by oxo at the C adjacent N; Z is N, NCO, CHNCOR1 or CHNR1, wherein R1 is alkyl (1-6C); and n is 0-5; wherein each Phi and Cy independently may optionally be substituted by alkyl (1-6C) or by halo, CF3, OCF3, NO2, NR2, OR, SR, COR, COOR, CONR2, NROCR or OOCR where R is H or alkyl (1-4C), or two substituents may form a 5-7 membered ring with the proviso that the compounds of formula (1) contain at least one aromatic moiety, are useful as calcium channel blockers.
Inventors:
Bellardetti, Francesco
Pajoheche, Hassan
Pajoheche, Hossein
Snatch, Terrance, Pee.
Tsamponi, Geralt, W.
Pajoheche, Hassan
Pajoheche, Hossein
Snatch, Terrance, Pee.
Tsamponi, Geralt, W.
Application Number:
JP2006504104A
Publication Date:
October 05, 2006
Filing Date:
April 08, 2004
Export Citation:
Assignee:
New Roamed Technologies, Inc.
International Classes:
C07D241/04; A61K31/4468; A61K31/451; A61K31/4515; A61K31/454; A61K31/4545; A61K31/495; A61K31/496; A61K31/498; A61K31/506; A61K31/5375; A61K31/538; A61K31/5415; A61P1/00; A61P3/10; A61P9/00; A61P9/10; A61P13/02; A61P25/04; A61P25/08; A61P25/22; A61P25/24; A61P29/00; A61P35/00; C07D211/14; C07D211/16; C07D211/46; C07D211/58; C07D213/38; C07D277/74; C07D277/82; C07D295/03; C07D295/16; C07D295/185; C07D311/82; C07D317/58; C07D317/60; C07D335/10; C07D401/04; C07D401/14; C07D403/04; C07D295/02
Foreign References:
| WO1995015958A1 | 1995-06-15 | |||
| WO2001045709A1 | 2001-06-28 |
Attorney, Agent or Firm:
Kato Asamichi
Kiuchi Uchida
Toshio Miyake
Kiuchi Uchida
Toshio Miyake